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Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness.

Bozek, Katarzyna ; Wei, Yuning ; Yan, Zheng ; Liu, Xiling ; Xiong, Jieyi ; Sugimoto, Masahiro ; Tomita, Masaru ; Pääbo, Svante ; Pieszek, Raik and Sherwood, Chet C , et al. (2014) In PLoS Biology 12(5).
Abstract
Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of... (More)
Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Biology
volume
12
issue
5
article number
e1001871
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:24866127
  • wos:000336969200021
  • scopus:84901435099
  • pmid:24866127
ISSN
1545-7885
DOI
10.1371/journal.pbio.1001871
language
English
LU publication?
yes
id
9b4f68d6-e2ee-4ed6-8992-3cc46a938e23 (old id 4452487)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24866127?dopt=Abstract
date added to LUP
2016-04-01 14:04:56
date last changed
2024-04-24 17:34:12
@article{9b4f68d6-e2ee-4ed6-8992-3cc46a938e23,
  abstract     = {{Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.}},
  author       = {{Bozek, Katarzyna and Wei, Yuning and Yan, Zheng and Liu, Xiling and Xiong, Jieyi and Sugimoto, Masahiro and Tomita, Masaru and Pääbo, Svante and Pieszek, Raik and Sherwood, Chet C and Hof, Patrick R and Ely, John J and Steinhauser, Dirk and Willmitzer, Lothar and Bangsbo, Jens and Hansson, Ola and Call, Josep and Giavalisco, Patrick and Khaitovich, Philipp}},
  issn         = {{1545-7885}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS Biology}},
  title        = {{Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness.}},
  url          = {{https://lup.lub.lu.se/search/files/3767499/5148432.pdf}},
  doi          = {{10.1371/journal.pbio.1001871}},
  volume       = {{12}},
  year         = {{2014}},
}