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Risk factors for carriage of AOM pathogens during the first 3 years of life in children with early onset of acute otitis media.

Gisselsson-Solén, Marie LU ; Henriksson, Gunnel LU ; Hermansson, Ann LU and Melhus, Åsa LU (2014) In Acta Oto-Laryngologica 134(7). p.684-690
Abstract
Abstract Conclusion: Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself. Objectives: The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM. Methods: Children with an onset of AOM before 6 months of age, indicating an 80% risk of developing rAOM, were enrolled in a vaccination trial on heptavalent PCV. These children were monitored for 3 years during healthy and AOM periods with nasopharyngeal cultures, physical examinations, and questionnaires. Results: A total of 109 children were included... (More)
Abstract Conclusion: Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself. Objectives: The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM. Methods: Children with an onset of AOM before 6 months of age, indicating an 80% risk of developing rAOM, were enrolled in a vaccination trial on heptavalent PCV. These children were monitored for 3 years during healthy and AOM periods with nasopharyngeal cultures, physical examinations, and questionnaires. Results: A total of 109 children were included at a mean age of 5 months; 105 were followed for 3 years, 89 (82%) of whom developed rAOM. Risk factors associated with increased carriage of all major AOM pathogens were age <2 years, concurrent AOM, and fulfilment of rAOM criteria. Having siblings in day care was associated with increased carriage of Streptococcus pneumoniae and Haemophilus influenzae, recent antibiotic treatment was associated with H. influenzae and Moraxella catarrhalis carriage, and winter season was associated with M. catarrhalis carriage alone. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oto-Laryngologica
volume
134
issue
7
pages
684 - 690
publisher
Taylor & Francis
external identifiers
  • pmid:24834935
  • wos:000337760700005
  • scopus:84902589934
ISSN
1651-2251
DOI
10.3109/00016489.2014.890291
language
English
LU publication?
yes
id
d504bbe8-fe90-46ea-9bd6-993ead6999d2 (old id 4454400)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24834935?dopt=Abstract
date added to LUP
2016-04-01 10:28:31
date last changed
2022-01-25 23:37:27
@article{d504bbe8-fe90-46ea-9bd6-993ead6999d2,
  abstract     = {{Abstract Conclusion: Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself. Objectives: The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM. Methods: Children with an onset of AOM before 6 months of age, indicating an 80% risk of developing rAOM, were enrolled in a vaccination trial on heptavalent PCV. These children were monitored for 3 years during healthy and AOM periods with nasopharyngeal cultures, physical examinations, and questionnaires. Results: A total of 109 children were included at a mean age of 5 months; 105 were followed for 3 years, 89 (82%) of whom developed rAOM. Risk factors associated with increased carriage of all major AOM pathogens were age &lt;2 years, concurrent AOM, and fulfilment of rAOM criteria. Having siblings in day care was associated with increased carriage of Streptococcus pneumoniae and Haemophilus influenzae, recent antibiotic treatment was associated with H. influenzae and Moraxella catarrhalis carriage, and winter season was associated with M. catarrhalis carriage alone.}},
  author       = {{Gisselsson-Solén, Marie and Henriksson, Gunnel and Hermansson, Ann and Melhus, Åsa}},
  issn         = {{1651-2251}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{684--690}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Oto-Laryngologica}},
  title        = {{Risk factors for carriage of AOM pathogens during the first 3 years of life in children with early onset of acute otitis media.}},
  url          = {{http://dx.doi.org/10.3109/00016489.2014.890291}},
  doi          = {{10.3109/00016489.2014.890291}},
  volume       = {{134}},
  year         = {{2014}},
}