PACAP and its receptors in migraine pathophysiology.
(2015) In British Journal of Pharmacology 172(19). p.4782-4784- Abstract
- Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors (PAC1 , VPAC1 and VPAC2 ) are present in sensory neurons and in vascular smooth muscle related to the trigeminovascular system, a key factor in migraine pain. Recent data point to an involvement of PACAP, and in particular the PAC1 receptor, in the pathophysiology of migraine. Available data are discussed in relation to a study by Walker in this issue of the Journal with the goal of identifying possibilities for the development of novel antagonists and to further define the role of PACAP in migraine pathophysiology and as a new target for antimigraine therapeutics.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4455244
- author
- Edvinsson, Lars LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Pharmacology
- volume
- 172
- issue
- 19
- pages
- 4782 - 4784
- publisher
- Wiley
- external identifiers
-
- pmid:24826981
- wos:000360918200016
- scopus:84940929822
- pmid:24826981
- ISSN
- 1476-5381
- DOI
- 10.1111/bph.12772
- language
- English
- LU publication?
- yes
- id
- dc2438b3-5bc0-4124-be65-b31751473495 (old id 4455244)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24826981?dopt=Abstract
- date added to LUP
- 2016-04-01 10:52:07
- date last changed
- 2024-10-07 15:22:11
@misc{dc2438b3-5bc0-4124-be65-b31751473495, abstract = {{Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors (PAC1 , VPAC1 and VPAC2 ) are present in sensory neurons and in vascular smooth muscle related to the trigeminovascular system, a key factor in migraine pain. Recent data point to an involvement of PACAP, and in particular the PAC1 receptor, in the pathophysiology of migraine. Available data are discussed in relation to a study by Walker in this issue of the Journal with the goal of identifying possibilities for the development of novel antagonists and to further define the role of PACAP in migraine pathophysiology and as a new target for antimigraine therapeutics.}}, author = {{Edvinsson, Lars}}, issn = {{1476-5381}}, language = {{eng}}, number = {{19}}, pages = {{4782--4784}}, publisher = {{Wiley}}, series = {{British Journal of Pharmacology}}, title = {{PACAP and its receptors in migraine pathophysiology.}}, url = {{http://dx.doi.org/10.1111/bph.12772}}, doi = {{10.1111/bph.12772}}, volume = {{172}}, year = {{2015}}, }