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PACAP and its receptors in migraine pathophysiology.

Edvinsson, Lars LU (2015) In British Journal of Pharmacology 172(19). p.4782-4784
Abstract
Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors (PAC1 , VPAC1 and VPAC2 ) are present in sensory neurons and in vascular smooth muscle related to the trigeminovascular system, a key factor in migraine pain. Recent data point to an involvement of PACAP, and in particular the PAC1 receptor, in the pathophysiology of migraine. Available data are discussed in relation to a study by Walker in this issue of the Journal with the goal of identifying possibilities for the development of novel antagonists and to further define the role of PACAP in migraine pathophysiology and as a new target for antimigraine therapeutics.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Pharmacology
volume
172
issue
19
pages
4782 - 4784
publisher
The British Pharmacological Society
external identifiers
  • pmid:24826981
  • wos:000360918200016
  • scopus:84940929822
ISSN
1476-5381
DOI
10.1111/bph.12772
language
English
LU publication?
yes
id
dc2438b3-5bc0-4124-be65-b31751473495 (old id 4455244)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24826981?dopt=Abstract
date added to LUP
2014-06-04 20:11:12
date last changed
2017-07-30 03:23:05
@misc{dc2438b3-5bc0-4124-be65-b31751473495,
  abstract     = {Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors (PAC1 , VPAC1 and VPAC2 ) are present in sensory neurons and in vascular smooth muscle related to the trigeminovascular system, a key factor in migraine pain. Recent data point to an involvement of PACAP, and in particular the PAC1 receptor, in the pathophysiology of migraine. Available data are discussed in relation to a study by Walker in this issue of the Journal with the goal of identifying possibilities for the development of novel antagonists and to further define the role of PACAP in migraine pathophysiology and as a new target for antimigraine therapeutics.},
  author       = {Edvinsson, Lars},
  issn         = {1476-5381},
  language     = {eng},
  number       = {19},
  pages        = {4782--4784},
  publisher    = {The British Pharmacological Society},
  series       = {British Journal of Pharmacology},
  title        = {PACAP and its receptors in migraine pathophysiology.},
  url          = {http://dx.doi.org/10.1111/bph.12772},
  volume       = {172},
  year         = {2015},
}