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RNA interference screening to detect targetable molecules in hematopoietic stem cells.

Karlsson, Christine LU ; Rak, Justyna LU and Larsson, Jonas LU (2014) In Current Opinion in Hematology 21(4). p.283-288
Abstract
The molecular principles regulating hematopoietic stem cells (HSCs) remain incompletely defined. In this review, we will discuss how RNA interference (RNAi) screening has emerged as a new and powerful tool to molecularly dissect various functional aspects of both normal and malignant HSCs, and how this may ultimately enable the discovery of novel therapeutic targets for clinical applications.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Hematology
volume
21
issue
4
pages
283 - 288
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:24811164
  • wos:000337155600006
  • scopus:84902266321
  • pmid:24811164
ISSN
1531-7048
DOI
10.1097/MOH.0000000000000053
language
English
LU publication?
yes
id
687036a7-4150-4bd3-8470-1f7e73cd4a85 (old id 4455633)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24811164?dopt=Abstract
date added to LUP
2016-04-01 10:53:52
date last changed
2022-02-02 22:02:13
@article{687036a7-4150-4bd3-8470-1f7e73cd4a85,
  abstract     = {{The molecular principles regulating hematopoietic stem cells (HSCs) remain incompletely defined. In this review, we will discuss how RNA interference (RNAi) screening has emerged as a new and powerful tool to molecularly dissect various functional aspects of both normal and malignant HSCs, and how this may ultimately enable the discovery of novel therapeutic targets for clinical applications.}},
  author       = {{Karlsson, Christine and Rak, Justyna and Larsson, Jonas}},
  issn         = {{1531-7048}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{283--288}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Current Opinion in Hematology}},
  title        = {{RNA interference screening to detect targetable molecules in hematopoietic stem cells.}},
  url          = {{http://dx.doi.org/10.1097/MOH.0000000000000053}},
  doi          = {{10.1097/MOH.0000000000000053}},
  volume       = {{21}},
  year         = {{2014}},
}