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Contact allergy to oxidized linalool and oxidized limonene : Patch testing in consecutive patients with dermatitis

Sukakul, Thanisorn LU orcid ; Bruze, Magnus LU ; Mowitz, Martin LU ; Antelmi, Annarita LU ; Bergendorff, Ola LU ; Björk, Jonas LU orcid ; Dahlin, Jakob LU ; Hamnerius, Nils LU ; Hauksson, Inese LU and Isaksson, Marléne LU , et al. (2022) In Contact Dermatitis 86(1). p.15-24
Abstract

BACKGROUND: Contact allergy to oxidized (ox.) linalool and ox. limonene has been reported to have a high prevalence, raising the question of inclusion into the baseline series. However, several important issues should be clarified and further investigated before inclusion can be warranted.

OBJECTIVES: To report the trends of ox. terpenes allergy in patients with dermatitis, features of the patch test reactions, and clinical characteristics of the patients.

METHODS: A retrospective analysis of 5773 patients was performed. All patients were patch tested with baseline series, individual ingredients of fragrance mix I and II, ox. linalool, and ox. limonene from 2013 to 2020.

RESULTS: The prevalence rates of contact allergy... (More)

BACKGROUND: Contact allergy to oxidized (ox.) linalool and ox. limonene has been reported to have a high prevalence, raising the question of inclusion into the baseline series. However, several important issues should be clarified and further investigated before inclusion can be warranted.

OBJECTIVES: To report the trends of ox. terpenes allergy in patients with dermatitis, features of the patch test reactions, and clinical characteristics of the patients.

METHODS: A retrospective analysis of 5773 patients was performed. All patients were patch tested with baseline series, individual ingredients of fragrance mix I and II, ox. linalool, and ox. limonene from 2013 to 2020.

RESULTS: The prevalence rates of contact allergy to ox. linalool and ox. limonene were 7.0% and 5.1%, respectively. Significantly increasing trends of contact allergy were observed. More than 95% of contact allergy cases were identified on Day 3/4. Patients with contact allergy to ox. linalool and ox. limonene were significantly younger than those with contact allergy to other fragrances and were predominantly female. Strong reactions were associated with older age and multiple fragrance allergies.

CONCLUSIONS: Contact allergy to ox. linalool and ox. limonene is becoming increasingly important, and findings show intriguing features. More studies concerning the clinical relevance before recommending these substances for screening are required.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
86
issue
1
pages
15 - 24
publisher
Wiley-Blackwell
external identifiers
  • pmid:34561893
  • scopus:85116819619
ISSN
0105-1873
DOI
10.1111/cod.13980
language
English
LU publication?
yes
id
4457ffd5-df96-453f-b125-905f8649790c
date added to LUP
2021-10-11 12:49:16
date last changed
2025-04-22 03:51:08
@article{4457ffd5-df96-453f-b125-905f8649790c,
  abstract     = {{<p>BACKGROUND: Contact allergy to oxidized (ox.) linalool and ox. limonene has been reported to have a high prevalence, raising the question of inclusion into the baseline series. However, several important issues should be clarified and further investigated before inclusion can be warranted.</p><p>OBJECTIVES: To report the trends of ox. terpenes allergy in patients with dermatitis, features of the patch test reactions, and clinical characteristics of the patients.</p><p>METHODS: A retrospective analysis of 5773 patients was performed. All patients were patch tested with baseline series, individual ingredients of fragrance mix I and II, ox. linalool, and ox. limonene from 2013 to 2020.</p><p>RESULTS: The prevalence rates of contact allergy to ox. linalool and ox. limonene were 7.0% and 5.1%, respectively. Significantly increasing trends of contact allergy were observed. More than 95% of contact allergy cases were identified on Day 3/4. Patients with contact allergy to ox. linalool and ox. limonene were significantly younger than those with contact allergy to other fragrances and were predominantly female. Strong reactions were associated with older age and multiple fragrance allergies.</p><p>CONCLUSIONS: Contact allergy to ox. linalool and ox. limonene is becoming increasingly important, and findings show intriguing features. More studies concerning the clinical relevance before recommending these substances for screening are required.</p>}},
  author       = {{Sukakul, Thanisorn and Bruze, Magnus and Mowitz, Martin and Antelmi, Annarita and Bergendorff, Ola and Björk, Jonas and Dahlin, Jakob and Hamnerius, Nils and Hauksson, Inese and Isaksson, Marléne and Lejding, Tina and Pontén, Ann and Svedman, Cecilia}},
  issn         = {{0105-1873}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{15--24}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Contact allergy to oxidized linalool and oxidized limonene : Patch testing in consecutive patients with dermatitis}},
  url          = {{http://dx.doi.org/10.1111/cod.13980}},
  doi          = {{10.1111/cod.13980}},
  volume       = {{86}},
  year         = {{2022}},
}