Risk of recurrence following delayed large flap reconstruction after mastectomy for breast cancer.
(2011) In British Journal of Surgery 98. p.659-666- Abstract
- BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. METHODS: Between 1982 and 2001, 125 women with previous invasive breast carcinoma underwent delayed large flap breast reconstruction with pedicled musculocutaneous or microvascular flaps (a median of 32 months after mastectomy). They were matched individually with 182 women with breast cancer who had a mastectomy but did not undergo breast... (More)
- BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. METHODS: Between 1982 and 2001, 125 women with previous invasive breast carcinoma underwent delayed large flap breast reconstruction with pedicled musculocutaneous or microvascular flaps (a median of 32 months after mastectomy). They were matched individually with 182 women with breast cancer who had a mastectomy but did not undergo breast reconstruction. Matching criteria were year of diagnosis, age at diagnosis and treating hospital. Medical records were evaluated until October 2007. Histopathological specimens for all included women were re-evaluated. The endpoint was locoregional or distant breast cancer recurrence. The risk of recurrent disease was calculated using a Cox proportional hazards analysis, adjusted for established prognostic factors. RESULTS: Median follow-up for the entire cohort was 146 months. The reconstruction group had a 2·08 (95 per cent confidence interval 1·07 to 4·06) times higher risk of recurrent disease than the mastectomy only group. CONCLUSION: Women with breast cancer who had delayed reconstruction with a large flap in this study had a higher risk of recurrent disease than those with mastectomy alone. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1831951
- author
- Isern, A E ; Manjer, Jonas LU ; Malina, J ; Loman, Niklas LU ; Mårtensson, Tuve ; Bofin, A ; Hagen, A I ; Tengrup, Ingrid ; Landberg, Göran LU and Ringberg, Anita LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Surgery
- volume
- 98
- pages
- 659 - 666
- publisher
- Oxford University Press
- external identifiers
-
- wos:000289262900010
- pmid:21312190
- scopus:79953729631
- pmid:21312190
- ISSN
- 1365-2168
- DOI
- 10.1002/bjs.7399
- language
- English
- LU publication?
- yes
- id
- 446ec039-8248-4d84-9d69-161712ae7cdf (old id 1831951)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21312190?dopt=Abstract
- date added to LUP
- 2016-04-04 08:30:36
- date last changed
- 2022-02-20 21:45:18
@article{446ec039-8248-4d84-9d69-161712ae7cdf,
abstract = {{BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. METHODS: Between 1982 and 2001, 125 women with previous invasive breast carcinoma underwent delayed large flap breast reconstruction with pedicled musculocutaneous or microvascular flaps (a median of 32 months after mastectomy). They were matched individually with 182 women with breast cancer who had a mastectomy but did not undergo breast reconstruction. Matching criteria were year of diagnosis, age at diagnosis and treating hospital. Medical records were evaluated until October 2007. Histopathological specimens for all included women were re-evaluated. The endpoint was locoregional or distant breast cancer recurrence. The risk of recurrent disease was calculated using a Cox proportional hazards analysis, adjusted for established prognostic factors. RESULTS: Median follow-up for the entire cohort was 146 months. The reconstruction group had a 2·08 (95 per cent confidence interval 1·07 to 4·06) times higher risk of recurrent disease than the mastectomy only group. CONCLUSION: Women with breast cancer who had delayed reconstruction with a large flap in this study had a higher risk of recurrent disease than those with mastectomy alone. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.}},
author = {{Isern, A E and Manjer, Jonas and Malina, J and Loman, Niklas and Mårtensson, Tuve and Bofin, A and Hagen, A I and Tengrup, Ingrid and Landberg, Göran and Ringberg, Anita}},
issn = {{1365-2168}},
language = {{eng}},
pages = {{659--666}},
publisher = {{Oxford University Press}},
series = {{British Journal of Surgery}},
title = {{Risk of recurrence following delayed large flap reconstruction after mastectomy for breast cancer.}},
url = {{http://dx.doi.org/10.1002/bjs.7399}},
doi = {{10.1002/bjs.7399}},
volume = {{98}},
year = {{2011}},
}