The glaucoma intensive treatment study : interim results from an ongoing longitudinal randomized clinical trial
Bengtsson, Boel LU ; Lindén, Christina ; Heijl, Anders LU ; Andersson-Geimer, Sabina LU ; Aspberg, Johan LU
and Jóhannesson, Gauti
(2022)
In Acta Ophthalmologica
100(2).
p.455-462
- Abstract
PURPOSE: The aim of the study was to determine the perimetric rate of glaucoma progression in the ongoing Glaucoma Intensive Treatment Study (GITS) after 3 years of follow-up.
DESIGN: This is a randomized, two-centre, prospective open-labelled treatment trial for open-angle glaucoma (OAG).
PARTICIPANTS: The participants of this study were treatment-naive patients with newly diagnosed OAG, aged 46-78 years, with early to moderate glaucomatous visual field loss scheduled to be followed for 5 years within the study.
METHODS: Patients were randomized to initial treatment with either topical monotherapy or with an intensive approach using drugs from three different classes, plus 360° laser trabeculoplasty. Changes in... (More)
PURPOSE: The aim of the study was to determine the perimetric rate of glaucoma progression in the ongoing Glaucoma Intensive Treatment Study (GITS) after 3 years of follow-up.
DESIGN: This is a randomized, two-centre, prospective open-labelled treatment trial for open-angle glaucoma (OAG).
PARTICIPANTS: The participants of this study were treatment-naive patients with newly diagnosed OAG, aged 46-78 years, with early to moderate glaucomatous visual field loss scheduled to be followed for 5 years within the study.
METHODS: Patients were randomized to initial treatment with either topical monotherapy or with an intensive approach using drugs from three different classes, plus 360° laser trabeculoplasty. Changes in treatment were allowed. Standard automated perimetry and tonometry were performed and side-effects documented. All results are presented using intention-to-treat analysis.
RESULTS: A total of 242 patients were randomized. After 3 years of follow-up, eight patients were lost to follow-up, six of whom were deceased. The median untreated baseline intraocular pressure (IOP) was 24 mmHg in both arms. The median IOP was almost constant over the 3 years of follow-up: ≈17 mmHg in the mono-arm and ≈14 mmHg in the multi-treatment arm. Treatment was intensified in 42% of the mono-treated patients and in 7% of the multi-treated patients. Treatment was reduced in 13% of the multi-treated patients. The median perimetric rate of progression was -0.5%/year in the mono-treated group and -0.1%/year in the multi-treated group (p = 0.03).
CONCLUSION: The rate of disease progression was significantly slower in the multi-treated patients than in the mono-treated patients. Further follow-up will show whether this difference is sustained over time.
(Less)
- author
- Bengtsson, Boel
LU
; Lindén, Christina
; Heijl, Anders
LU
; Andersson-Geimer, Sabina
LU
; Aspberg, Johan
LU
and Jóhannesson, Gauti
- organization
- publishing date
- 2022-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Ophthalmologica
- volume
- 100
- issue
- 2
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85111523268
- pmid:34327833
- ISSN
- 1755-3768
- DOI
- 10.1111/aos.14978
- language
- English
- LU publication?
- yes
- id
- 446f0bbe-b3f9-48b1-9586-936a4d56b303
- date added to LUP
- 2021-08-18 12:18:32
- date last changed
- 2024-04-20 09:42:36
@article{446f0bbe-b3f9-48b1-9586-936a4d56b303,
abstract = {{<p>PURPOSE: The aim of the study was to determine the perimetric rate of glaucoma progression in the ongoing Glaucoma Intensive Treatment Study (GITS) after 3 years of follow-up.</p><p>DESIGN: This is a randomized, two-centre, prospective open-labelled treatment trial for open-angle glaucoma (OAG).</p><p>PARTICIPANTS: The participants of this study were treatment-naive patients with newly diagnosed OAG, aged 46-78 years, with early to moderate glaucomatous visual field loss scheduled to be followed for 5 years within the study.</p><p>METHODS: Patients were randomized to initial treatment with either topical monotherapy or with an intensive approach using drugs from three different classes, plus 360° laser trabeculoplasty. Changes in treatment were allowed. Standard automated perimetry and tonometry were performed and side-effects documented. All results are presented using intention-to-treat analysis.</p><p>RESULTS: A total of 242 patients were randomized. After 3 years of follow-up, eight patients were lost to follow-up, six of whom were deceased. The median untreated baseline intraocular pressure (IOP) was 24 mmHg in both arms. The median IOP was almost constant over the 3 years of follow-up: ≈17 mmHg in the mono-arm and ≈14 mmHg in the multi-treatment arm. Treatment was intensified in 42% of the mono-treated patients and in 7% of the multi-treated patients. Treatment was reduced in 13% of the multi-treated patients. The median perimetric rate of progression was -0.5%/year in the mono-treated group and -0.1%/year in the multi-treated group (p = 0.03).</p><p>CONCLUSION: The rate of disease progression was significantly slower in the multi-treated patients than in the mono-treated patients. Further follow-up will show whether this difference is sustained over time.</p>}},
author = {{Bengtsson, Boel and Lindén, Christina and Heijl, Anders and Andersson-Geimer, Sabina and Aspberg, Johan and Jóhannesson, Gauti}},
issn = {{1755-3768}},
language = {{eng}},
number = {{2}},
pages = {{455--462}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Ophthalmologica}},
title = {{The glaucoma intensive treatment study : interim results from an ongoing longitudinal randomized clinical trial}},
url = {{http://dx.doi.org/10.1111/aos.14978}},
doi = {{10.1111/aos.14978}},
volume = {{100}},
year = {{2022}},
}