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Immune responses to hair dyes containing toluene-2,5-diamine

Schmidt, J. D.; Johansen, J. D.; Nielsen, M. M.; Zimersson, E.; Svedman, Cecilia LU ; Bruze, Magnus LU ; Engkilde, K.; Poulsen, S. S.; Geisler, C. and Bonefeld, C. M. (2014) In British Journal of Dermatology 170(2). p.352-359
Abstract
Background



Toluene-2,5-diamine (PTD) is the most frequently used dye in oxidative hair dyes on the Scandinavian market. However, little is known about immune responses to PTD-containing oxidative hair dyes.

Objectives



To study immune responses induced by PTD-containing hair dyes in mice.

Methods



Immune responses against two different permanent hair dye products containing 1·60% (w/w) and 0·48% (w/w) PTD within the colour gel, and various concentrations of pure PTD were studied. The local inflammatory response was measured by ear swelling and cell infiltration, and T- and B-cell infiltration and proliferation was determined in the draining lymph nodes.

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Background



Toluene-2,5-diamine (PTD) is the most frequently used dye in oxidative hair dyes on the Scandinavian market. However, little is known about immune responses to PTD-containing oxidative hair dyes.

Objectives



To study immune responses induced by PTD-containing hair dyes in mice.

Methods



Immune responses against two different permanent hair dye products containing 1·60% (w/w) and 0·48% (w/w) PTD within the colour gel, and various concentrations of pure PTD were studied. The local inflammatory response was measured by ear swelling and cell infiltration, and T- and B-cell infiltration and proliferation was determined in the draining lymph nodes.

Results



Concentration-dependent immune responses were seen to PTD both in the skin and draining lymph nodes. The hair dye containing 1·60% PTD induced strong local inflammation and caused T- and B-cell infiltration and proliferation as well as an increased number of regulatory T cells in the draining lymph nodes. In contrast, the hair dye containing 0·48% PTD induced skin inflammation but only minor responses in the draining lymph nodes.

Conclusions



Consumer-available PTD-containing permanent hair dyes can be potent immune activators inducing both pro- and anti-inflammatory responses. The outcome of the response is dependent on allergen dose, amount of additional allergens and exposure regime. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Dermatology
volume
170
issue
2
pages
352 - 359
publisher
Wiley-Blackwell
external identifiers
  • wos:000331358800018
  • scopus:84894242752
ISSN
1365-2133
DOI
10.1111/bjd.12676
language
English
LU publication?
yes
id
3f0f5481-2dc5-40f5-8cbf-9c17cee94ee0 (old id 4470351)
date added to LUP
2014-07-01 07:38:29
date last changed
2017-08-13 03:23:44
@article{3f0f5481-2dc5-40f5-8cbf-9c17cee94ee0,
  abstract     = {Background<br/><br>
<br/><br>
Toluene-2,5-diamine (PTD) is the most frequently used dye in oxidative hair dyes on the Scandinavian market. However, little is known about immune responses to PTD-containing oxidative hair dyes.<br/><br>
Objectives<br/><br>
<br/><br>
To study immune responses induced by PTD-containing hair dyes in mice.<br/><br>
Methods<br/><br>
<br/><br>
Immune responses against two different permanent hair dye products containing 1·60% (w/w) and 0·48% (w/w) PTD within the colour gel, and various concentrations of pure PTD were studied. The local inflammatory response was measured by ear swelling and cell infiltration, and T- and B-cell infiltration and proliferation was determined in the draining lymph nodes.<br/><br>
Results<br/><br>
<br/><br>
Concentration-dependent immune responses were seen to PTD both in the skin and draining lymph nodes. The hair dye containing 1·60% PTD induced strong local inflammation and caused T- and B-cell infiltration and proliferation as well as an increased number of regulatory T cells in the draining lymph nodes. In contrast, the hair dye containing 0·48% PTD induced skin inflammation but only minor responses in the draining lymph nodes.<br/><br>
Conclusions<br/><br>
<br/><br>
Consumer-available PTD-containing permanent hair dyes can be potent immune activators inducing both pro- and anti-inflammatory responses. The outcome of the response is dependent on allergen dose, amount of additional allergens and exposure regime.},
  author       = {Schmidt, J. D. and Johansen, J. D. and Nielsen, M. M. and Zimersson, E. and Svedman, Cecilia and Bruze, Magnus and Engkilde, K. and Poulsen, S. S. and Geisler, C. and Bonefeld, C. M.},
  issn         = {1365-2133},
  language     = {eng},
  number       = {2},
  pages        = {352--359},
  publisher    = {Wiley-Blackwell},
  series       = {British Journal of Dermatology},
  title        = {Immune responses to hair dyes containing toluene-2,5-diamine},
  url          = {http://dx.doi.org/10.1111/bjd.12676},
  volume       = {170},
  year         = {2014},
}