Usefulness of Symptoms to Screen for Celiac Disease
(2014) In Pediatrics 133(2). p.211-218- Abstract
- OBJECTIVE: To describe the frequency of symptoms and associated conditions among screening-detected celiac disease (CD) cases and non-CD children and to evaluate questionnaire-based case-finding targeting the general population. METHODS: In a population-based CD screening of 12-year-olds, children and their parents completed questionnaires on CD-associated symptoms and conditions before knowledge of CD status. Questionnaire data for those who had their CD detected in the screening (n = 153) were compared with those of children with normal levels of CD markers (n = 7016). Hypothetical case-finding strategies were also evaluated. Questionnaires were returned by 7054 ( 98%) of the children and by 6294 ( 88%) of their parents. RESULTS:... (More)
- OBJECTIVE: To describe the frequency of symptoms and associated conditions among screening-detected celiac disease (CD) cases and non-CD children and to evaluate questionnaire-based case-finding targeting the general population. METHODS: In a population-based CD screening of 12-year-olds, children and their parents completed questionnaires on CD-associated symptoms and conditions before knowledge of CD status. Questionnaire data for those who had their CD detected in the screening (n = 153) were compared with those of children with normal levels of CD markers (n = 7016). Hypothetical case-finding strategies were also evaluated. Questionnaires were returned by 7054 ( 98%) of the children and by 6294 ( 88%) of their parents. RESULTS: Symptoms were as common among screening-detected CD cases as among non-CD children. The frequency of children with screening-detected CD was similar when comparing the groups with and without any CD-related symptoms (2.1% vs 2.1%; P =.930) or CD-associated conditions (3.6% vs 2.1%; P =.07). Case-finding by asking for CD-associated symptoms and/or conditions would have identified 52 cases (38% of all cases) at a cost of analyzing blood samples for 2282 children (37%) in the study population. CONCLUSIONS: The current recommended guidelines for finding undiagnosed CD cases, so-called active case-finding, fail to identify the majority of previously undiagnosed cases if applied in the general population of Swedish 12- year-olds. Our results warrant further studies on the effectiveness of CD case-finding in the pediatric population, both at the clinical and population-based levels. Pediatrics 2014; 133: 211- 218 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4470362
- author
- Rosen, Anna
; Sandstrom, Olof
; Carlsson, Annelie
LU
; Hogberg, Lotta ; Olen, Ola ; Stenlund, Hans and Ivarsson, Anneli
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- case-finding, celiac disease, questionnaire, screening, symptom
- in
- Pediatrics
- volume
- 133
- issue
- 2
- pages
- 211 - 218
- publisher
- American Academy of Pediatrics
- external identifiers
-
- wos:000333413600006
- scopus:84893274411
- pmid:24420802
- ISSN
- 1098-4275
- DOI
- 10.1542/peds.2012-3765
- language
- English
- LU publication?
- yes
- id
- ade2d45f-f310-49b4-a031-bb559530cc85 (old id 4470362)
- date added to LUP
- 2016-04-01 14:00:43
- date last changed
- 2022-02-19 08:41:40
@article{ade2d45f-f310-49b4-a031-bb559530cc85, abstract = {{OBJECTIVE: To describe the frequency of symptoms and associated conditions among screening-detected celiac disease (CD) cases and non-CD children and to evaluate questionnaire-based case-finding targeting the general population. METHODS: In a population-based CD screening of 12-year-olds, children and their parents completed questionnaires on CD-associated symptoms and conditions before knowledge of CD status. Questionnaire data for those who had their CD detected in the screening (n = 153) were compared with those of children with normal levels of CD markers (n = 7016). Hypothetical case-finding strategies were also evaluated. Questionnaires were returned by 7054 ( 98%) of the children and by 6294 ( 88%) of their parents. RESULTS: Symptoms were as common among screening-detected CD cases as among non-CD children. The frequency of children with screening-detected CD was similar when comparing the groups with and without any CD-related symptoms (2.1% vs 2.1%; P =.930) or CD-associated conditions (3.6% vs 2.1%; P =.07). Case-finding by asking for CD-associated symptoms and/or conditions would have identified 52 cases (38% of all cases) at a cost of analyzing blood samples for 2282 children (37%) in the study population. CONCLUSIONS: The current recommended guidelines for finding undiagnosed CD cases, so-called active case-finding, fail to identify the majority of previously undiagnosed cases if applied in the general population of Swedish 12- year-olds. Our results warrant further studies on the effectiveness of CD case-finding in the pediatric population, both at the clinical and population-based levels. Pediatrics 2014; 133: 211- 218}}, author = {{Rosen, Anna and Sandstrom, Olof and Carlsson, Annelie and Hogberg, Lotta and Olen, Ola and Stenlund, Hans and Ivarsson, Anneli}}, issn = {{1098-4275}}, keywords = {{case-finding; celiac disease; questionnaire; screening; symptom}}, language = {{eng}}, number = {{2}}, pages = {{211--218}}, publisher = {{American Academy of Pediatrics}}, series = {{Pediatrics}}, title = {{Usefulness of Symptoms to Screen for Celiac Disease}}, url = {{http://dx.doi.org/10.1542/peds.2012-3765}}, doi = {{10.1542/peds.2012-3765}}, volume = {{133}}, year = {{2014}}, }