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Preparation and physicochemical characteristics of cryogel based on gelatin and oxidised dextran

Berillo, Dmitry LU and Volkova, Natalia LU (2014) In Journal of Materials Science 49(14). p.4855-4868
Abstract
In this study, a novel method of preparation of cryogels based on oxidised dextran (Ox.D) and gelatin (Gel) without sodium borohydride is proposed. The physico-chemical properties of obtained hydrogels were investigated. It was found that the stability of cryogels Ox.D-Gel is significantly depended on pH, and mechanical properties were improved after the freeze drying. The schemes of the reactions between Ox.D and Gel at different steps of the treatment of the material were suggested. According to H-1-NMR data, the Amadori rearrangement occurred under the step of cryogelation. The increase of cross-linking degree through the formation of additional Schiff's base group was observed as a result of incubation at high humidities or elevated... (More)
In this study, a novel method of preparation of cryogels based on oxidised dextran (Ox.D) and gelatin (Gel) without sodium borohydride is proposed. The physico-chemical properties of obtained hydrogels were investigated. It was found that the stability of cryogels Ox.D-Gel is significantly depended on pH, and mechanical properties were improved after the freeze drying. The schemes of the reactions between Ox.D and Gel at different steps of the treatment of the material were suggested. According to H-1-NMR data, the Amadori rearrangement occurred under the step of cryogelation. The increase of cross-linking degree through the formation of additional Schiff's base group was observed as a result of incubation at high humidities or elevated temperature (60 A degrees C). The obtained cryogels can be used as biocompatible and biodegradable scaffolds for proliferation of cells or other biomedical applications. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Science
volume
49
issue
14
pages
4855 - 4868
publisher
Springer
external identifiers
  • wos:000335451700019
  • scopus:84900497725
ISSN
0022-2461
DOI
10.1007/s10853-014-8186-3
language
English
LU publication?
yes
id
6f6557d8-fb57-4e88-a022-6995e45637bd (old id 4470472)
date added to LUP
2014-06-19 12:29:53
date last changed
2017-10-01 04:29:36
@article{6f6557d8-fb57-4e88-a022-6995e45637bd,
  abstract     = {In this study, a novel method of preparation of cryogels based on oxidised dextran (Ox.D) and gelatin (Gel) without sodium borohydride is proposed. The physico-chemical properties of obtained hydrogels were investigated. It was found that the stability of cryogels Ox.D-Gel is significantly depended on pH, and mechanical properties were improved after the freeze drying. The schemes of the reactions between Ox.D and Gel at different steps of the treatment of the material were suggested. According to H-1-NMR data, the Amadori rearrangement occurred under the step of cryogelation. The increase of cross-linking degree through the formation of additional Schiff's base group was observed as a result of incubation at high humidities or elevated temperature (60 A degrees C). The obtained cryogels can be used as biocompatible and biodegradable scaffolds for proliferation of cells or other biomedical applications.},
  author       = {Berillo, Dmitry and Volkova, Natalia},
  issn         = {0022-2461},
  language     = {eng},
  number       = {14},
  pages        = {4855--4868},
  publisher    = {Springer},
  series       = {Journal of Materials Science},
  title        = {Preparation and physicochemical characteristics of cryogel based on gelatin and oxidised dextran},
  url          = {http://dx.doi.org/10.1007/s10853-014-8186-3},
  volume       = {49},
  year         = {2014},
}