Advanced

Quantitative versus semiquantitative MR imaging of cartilage in blood-induced arthritic ankles: preliminary findings

Doria, Andrea S.; Zhang, Ningning; Lundin, Björn LU ; Hilliard, Pamela; Man, Carina; Weiss, Ruth; Detzler, Gary; Blanchette, Victor; Moineddin, Rahim and Eckstein, Felix, et al. (2014) In Pediatric Radiology 44(5). p.576-586
Abstract
Recent advances in hemophilia prophylaxis have raised the need for accurate noninvasive methods for assessment of early cartilage damage in maturing joints to guide initiation of prophylaxis. Such methods can either be semiquantitative or quantitative. Whereas semiquantitative scores are less time-consuming to be performed than quantitative methods, they are prone to subjective interpretation. To test the feasibility of a manual segmentation and a quantitative methodology for cross-sectional evaluation of articular cartilage status in growing ankles of children with blood-induced arthritis, as compared with a semiquantitative scoring system and clinical-radiographic constructs. Twelve boys, 11 with hemophilia (A, n = 9; B, n = 2) and 1... (More)
Recent advances in hemophilia prophylaxis have raised the need for accurate noninvasive methods for assessment of early cartilage damage in maturing joints to guide initiation of prophylaxis. Such methods can either be semiquantitative or quantitative. Whereas semiquantitative scores are less time-consuming to be performed than quantitative methods, they are prone to subjective interpretation. To test the feasibility of a manual segmentation and a quantitative methodology for cross-sectional evaluation of articular cartilage status in growing ankles of children with blood-induced arthritis, as compared with a semiquantitative scoring system and clinical-radiographic constructs. Twelve boys, 11 with hemophilia (A, n = 9; B, n = 2) and 1 with von Willebrand disease (median age: 13; range: 6-17), underwent physical examination and MRI at 1.5 T. Two radiologists semiquantitatively scored the MRIs for cartilage pathology (surface erosions, cartilage loss) with blinding to clinical information. An experienced operator applied a validated quantitative 3-D MRI method to determine the percentage area of denuded bone (dAB) and the cartilage thickness (ThCtAB) in the joints' MRIs. Quantitative and semiquantitative MRI methods and clinical-radiographic constructs (Hemophilia Joint Health Score [HJHS], Pettersson radiograph scores) were compared. Moderate correlations were noted between erosions and dAB (r = 0.62, P = 0.03) in the talus but not in the distal tibia (P > 0.05). Whereas substantial to high correlations (r range: 0.70-0.94, P < 0.05) were observed between erosions, cartilage loss, HJHS and Pettersson scores both at the distal tibia and talus levels, moderate/borderline substantial (r range: 0.55-0.61, P < 0.05) correlations were noted between dAB/ThCtAB and clinical-radiographic constructs. Whereas the semiquantitative method of assessing cartilage status is closely associated with clinical-radiographic scores in cross-sectional studies of blood-induced arthropathy, quantitative measures provide independent information and are therefore less applicable for that research design. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood-induced arthritis, Hemophilia, Blood-induced arthropathy, Children, Ankles, Cartilage, Magnetic resonance imaging
in
Pediatric Radiology
volume
44
issue
5
pages
576 - 586
publisher
Springer
external identifiers
  • wos:000334513800009
  • scopus:84922226472
ISSN
1432-1998
DOI
10.1007/s00247-013-2872-1
language
English
LU publication?
yes
id
706c9252-ea0b-4c41-ad64-5afcd277c154 (old id 4488291)
date added to LUP
2014-07-01 07:34:19
date last changed
2017-01-01 06:07:15
@article{706c9252-ea0b-4c41-ad64-5afcd277c154,
  abstract     = {Recent advances in hemophilia prophylaxis have raised the need for accurate noninvasive methods for assessment of early cartilage damage in maturing joints to guide initiation of prophylaxis. Such methods can either be semiquantitative or quantitative. Whereas semiquantitative scores are less time-consuming to be performed than quantitative methods, they are prone to subjective interpretation. To test the feasibility of a manual segmentation and a quantitative methodology for cross-sectional evaluation of articular cartilage status in growing ankles of children with blood-induced arthritis, as compared with a semiquantitative scoring system and clinical-radiographic constructs. Twelve boys, 11 with hemophilia (A, n = 9; B, n = 2) and 1 with von Willebrand disease (median age: 13; range: 6-17), underwent physical examination and MRI at 1.5 T. Two radiologists semiquantitatively scored the MRIs for cartilage pathology (surface erosions, cartilage loss) with blinding to clinical information. An experienced operator applied a validated quantitative 3-D MRI method to determine the percentage area of denuded bone (dAB) and the cartilage thickness (ThCtAB) in the joints' MRIs. Quantitative and semiquantitative MRI methods and clinical-radiographic constructs (Hemophilia Joint Health Score [HJHS], Pettersson radiograph scores) were compared. Moderate correlations were noted between erosions and dAB (r = 0.62, P = 0.03) in the talus but not in the distal tibia (P &gt; 0.05). Whereas substantial to high correlations (r range: 0.70-0.94, P &lt; 0.05) were observed between erosions, cartilage loss, HJHS and Pettersson scores both at the distal tibia and talus levels, moderate/borderline substantial (r range: 0.55-0.61, P &lt; 0.05) correlations were noted between dAB/ThCtAB and clinical-radiographic constructs. Whereas the semiquantitative method of assessing cartilage status is closely associated with clinical-radiographic scores in cross-sectional studies of blood-induced arthropathy, quantitative measures provide independent information and are therefore less applicable for that research design.},
  author       = {Doria, Andrea S. and Zhang, Ningning and Lundin, Björn and Hilliard, Pamela and Man, Carina and Weiss, Ruth and Detzler, Gary and Blanchette, Victor and Moineddin, Rahim and Eckstein, Felix and Sussman, Marshall S.},
  issn         = {1432-1998},
  keyword      = {Blood-induced arthritis,Hemophilia,Blood-induced arthropathy,Children,Ankles,Cartilage,Magnetic resonance imaging},
  language     = {eng},
  number       = {5},
  pages        = {576--586},
  publisher    = {Springer},
  series       = {Pediatric Radiology},
  title        = {Quantitative versus semiquantitative MR imaging of cartilage in blood-induced arthritic ankles: preliminary findings},
  url          = {http://dx.doi.org/10.1007/s00247-013-2872-1},
  volume       = {44},
  year         = {2014},
}