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No association of primary Sjogren's syndrome with Fc gamma receptor gene variants

Haldorsen, K. ; Appel, S. ; Le Hellard, S. ; Bruland, O. ; Brun, J. G. ; Omdal, R. ; Kristjansdottir, G. ; Theander, Elke LU ; Fernandes, C. P. D. and Kvarnstrom, M. , et al. (2013) In Genes and Immunity 14(4). p.234-237
Abstract
The genetic background of primary Sjogren's syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are important for clearance of immune complexes. Fcg receptor variants and gene deletion have been found to confer SLE risk. In this study, four Fc gamma receptor single-nucleotide polymorphisms (SNPs) and one copy number variation (CNV) were studied. Swedish and Norwegian pSS patients (N = 527) and controls (N = 528) were genotyped for the Fc gamma receptor gene variant FCGR2A H131R (rs1801274) by the Illumina GoldenGate assay. FCGR3A F158V (rs396991) was analysed in 488 patients and 485 controls, FCGR3B rs447536 was analysed in 471 patients and 467 controls, and FCGR3B rs448740 was analysed in... (More)
The genetic background of primary Sjogren's syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are important for clearance of immune complexes. Fcg receptor variants and gene deletion have been found to confer SLE risk. In this study, four Fc gamma receptor single-nucleotide polymorphisms (SNPs) and one copy number variation (CNV) were studied. Swedish and Norwegian pSS patients (N = 527) and controls (N = 528) were genotyped for the Fc gamma receptor gene variant FCGR2A H131R (rs1801274) by the Illumina GoldenGate assay. FCGR3A F158V (rs396991) was analysed in 488 patients and 485 controls, FCGR3B rs447536 was analysed in 471 patients and 467 controls, and FCGR3B rs448740 was analysed in 478 cases and 455 controls, using TaqMan SNP genotyping assays. FCGR3B CNV was analysed in 124 patients and 139 controls using a TaqMan copy number assay. None of the SNPs showed any association with pSS. Also, no FCGR3B CNV association was detected. The lack of association of pSS with Fc gamma receptor gene variants indicates that defective immune complex clearance may not be as important in pSS pathogenesis as in SLE, and may point to important differences between SLE and pSS. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sjogren's syndrome, Fc gamma receptors, single-nucleotide polymorphism, DNA copy number variations
in
Genes and Immunity
volume
14
issue
4
pages
234 - 237
publisher
Nature Publishing Group
external identifiers
  • wos:000320029300005
  • scopus:84878937537
  • pmid:23552400
ISSN
1476-5470
DOI
10.1038/gene.2013.12
language
English
LU publication?
yes
id
448e13d8-e12a-4d16-a751-26e15e6ee79b (old id 3927148)
date added to LUP
2016-04-01 09:51:25
date last changed
2020-01-05 03:21:16
@article{448e13d8-e12a-4d16-a751-26e15e6ee79b,
  abstract     = {The genetic background of primary Sjogren's syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are important for clearance of immune complexes. Fcg receptor variants and gene deletion have been found to confer SLE risk. In this study, four Fc gamma receptor single-nucleotide polymorphisms (SNPs) and one copy number variation (CNV) were studied. Swedish and Norwegian pSS patients (N = 527) and controls (N = 528) were genotyped for the Fc gamma receptor gene variant FCGR2A H131R (rs1801274) by the Illumina GoldenGate assay. FCGR3A F158V (rs396991) was analysed in 488 patients and 485 controls, FCGR3B rs447536 was analysed in 471 patients and 467 controls, and FCGR3B rs448740 was analysed in 478 cases and 455 controls, using TaqMan SNP genotyping assays. FCGR3B CNV was analysed in 124 patients and 139 controls using a TaqMan copy number assay. None of the SNPs showed any association with pSS. Also, no FCGR3B CNV association was detected. The lack of association of pSS with Fc gamma receptor gene variants indicates that defective immune complex clearance may not be as important in pSS pathogenesis as in SLE, and may point to important differences between SLE and pSS.},
  author       = {Haldorsen, K. and Appel, S. and Le Hellard, S. and Bruland, O. and Brun, J. G. and Omdal, R. and Kristjansdottir, G. and Theander, Elke and Fernandes, C. P. D. and Kvarnstrom, M. and Eriksson, P. and Ronnblom, L. and Herlenius, M. W. and Nordmark, G. and Jonsson, R. and Bolstad, A. I.},
  issn         = {1476-5470},
  language     = {eng},
  number       = {4},
  pages        = {234--237},
  publisher    = {Nature Publishing Group},
  series       = {Genes and Immunity},
  title        = {No association of primary Sjogren's syndrome with Fc gamma receptor gene variants},
  url          = {http://dx.doi.org/10.1038/gene.2013.12},
  doi          = {10.1038/gene.2013.12},
  volume       = {14},
  year         = {2013},
}