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Skin application of glutathione and iron sulfate can inhibit elicitation of allergic contact dermatitis from hexavalent chromium

Lejding, Tina LU ; Engfeldt, Malin LU ; Bruze, Magnus LU ; Isaksson, Marléne LU ; Svedman, Cecilia LU ; Zimerson, Erik LU ; Verma, Kaushal and Mowitz, Martin LU (2020) In Contact Dermatitis 82(1). p.45-53
Abstract

Background: Allergic contact dermatitis (ACD) caused by hexavalent chromium, Cr(VI), is often severe and difficult to treat. The most common source of exposure to Cr(VI) in Sweden used to be cement, and more recently leather. The contact allergy can be diminished or inhibited if the exposure is decreased or ceases. Barrier creams against different kinds of allergens have been investigated for their protective properties which may offer protection against Cr(VI) exposure. Objectives: To investigate the capacity of formulas containing glutathione (GSH) and iron sulfate to inhibit elicitation of ACD in Cr(VI)-allergic individuals when exposed to Cr(VI). Methods: In 18 Cr(VI)-allergic volunteers the back was divided into eight patch test... (More)

Background: Allergic contact dermatitis (ACD) caused by hexavalent chromium, Cr(VI), is often severe and difficult to treat. The most common source of exposure to Cr(VI) in Sweden used to be cement, and more recently leather. The contact allergy can be diminished or inhibited if the exposure is decreased or ceases. Barrier creams against different kinds of allergens have been investigated for their protective properties which may offer protection against Cr(VI) exposure. Objectives: To investigate the capacity of formulas containing glutathione (GSH) and iron sulfate to inhibit elicitation of ACD in Cr(VI)-allergic individuals when exposed to Cr(VI). Methods: In 18 Cr(VI)-allergic volunteers the back was divided into eight patch test areas which were treated with preparations of possible barrier creams, prior to patch testing with a dilution series of potassium dichromate and a buffered extract of cement. Results: A significant reduction in reactivity to Cr(VI) and cement extract on skin treated with formulas containing GSH or iron sulfate was noticed, compared with untreated skin. Conclusion: Formulas containing GSH or iron sulfate in barrier creams inhibit ACD in individuals allergic to Cr(VI) when applied before exposure to Cr(VI) and cement extract.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, barrier cream, chromate, contact allergy, Cr(III), Cr(VI), delayed hypersensitivity, hexavalent chromium, patch testing, prevention, trivalent chromium
in
Contact Dermatitis
volume
82
issue
1
pages
45 - 53
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85075443995
  • pmid:31584201
ISSN
0105-1873
DOI
10.1111/cod.13409
language
English
LU publication?
yes
id
4493e2f7-533d-4f80-9bf6-3dd8fbca2c1e
date added to LUP
2019-12-09 08:53:32
date last changed
2020-01-14 15:55:47
@article{4493e2f7-533d-4f80-9bf6-3dd8fbca2c1e,
  abstract     = {<p>Background: Allergic contact dermatitis (ACD) caused by hexavalent chromium, Cr(VI), is often severe and difficult to treat. The most common source of exposure to Cr(VI) in Sweden used to be cement, and more recently leather. The contact allergy can be diminished or inhibited if the exposure is decreased or ceases. Barrier creams against different kinds of allergens have been investigated for their protective properties which may offer protection against Cr(VI) exposure. Objectives: To investigate the capacity of formulas containing glutathione (GSH) and iron sulfate to inhibit elicitation of ACD in Cr(VI)-allergic individuals when exposed to Cr(VI). Methods: In 18 Cr(VI)-allergic volunteers the back was divided into eight patch test areas which were treated with preparations of possible barrier creams, prior to patch testing with a dilution series of potassium dichromate and a buffered extract of cement. Results: A significant reduction in reactivity to Cr(VI) and cement extract on skin treated with formulas containing GSH or iron sulfate was noticed, compared with untreated skin. Conclusion: Formulas containing GSH or iron sulfate in barrier creams inhibit ACD in individuals allergic to Cr(VI) when applied before exposure to Cr(VI) and cement extract.</p>},
  author       = {Lejding, Tina and Engfeldt, Malin and Bruze, Magnus and Isaksson, Marléne and Svedman, Cecilia and Zimerson, Erik and Verma, Kaushal and Mowitz, Martin},
  issn         = {0105-1873},
  language     = {eng},
  number       = {1},
  pages        = {45--53},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Skin application of glutathione and iron sulfate can inhibit elicitation of allergic contact dermatitis from hexavalent chromium},
  url          = {http://dx.doi.org/10.1111/cod.13409},
  doi          = {10.1111/cod.13409},
  volume       = {82},
  year         = {2020},
}