Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae
(2005) In Topics in Current Genetics 12. p.87-120- Abstract
- Transfer RNAs are adaptor molecules, which decode mRNA into protein and,
thereby, play a central role in gene expression. During the maturation of a primary
tRNA transcript, specific subsets of the four normal nucleosides adenosine,
cytidine, guanosine, and uridine are modified. The formation of a modified nucleoside
can require more than one gene product and may involve several enzymatic
steps. In the last few years, the identification of gene products required for
formation of modified nucleosides in tRNA has dramatically increased. In this review,
proteins involved in modification of cytoplasmic tRNAs in Saccharomyces
cerevisiae are described, emphasizing phenotypic characteristics of... (More) - Transfer RNAs are adaptor molecules, which decode mRNA into protein and,
thereby, play a central role in gene expression. During the maturation of a primary
tRNA transcript, specific subsets of the four normal nucleosides adenosine,
cytidine, guanosine, and uridine are modified. The formation of a modified nucleoside
can require more than one gene product and may involve several enzymatic
steps. In the last few years, the identification of gene products required for
formation of modified nucleosides in tRNA has dramatically increased. In this review,
proteins involved in modification of cytoplasmic tRNAs in Saccharomyces
cerevisiae are described, emphasizing phenotypic characteristics of modification
deficient strains and genetic approaches used to determine the in vivo role of
modified nucleosides/ modifying enzymes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/45035b6c-a566-4a33-91fc-5e7efa50a882
- author
- Johansson, Marcus J.O. LU and Byström, Anders S.
- publishing date
- 2005-01-07
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- host publication
- Fine-Tuning of RNA Functions by Modification and Editing
- series title
- Topics in Current Genetics
- editor
- Grosjean, Henri
- volume
- 12
- pages
- 87 - 120
- ISSN
- 1610-2096
- 1610-6970
- ISBN
- 978-3-540-31454-7
- 978-3-540-24495-0
- DOI
- 10.1007/b105814
- language
- English
- LU publication?
- no
- id
- 45035b6c-a566-4a33-91fc-5e7efa50a882
- date added to LUP
- 2024-03-06 14:35:15
- date last changed
- 2024-03-07 07:37:27
@inbook{45035b6c-a566-4a33-91fc-5e7efa50a882, abstract = {{Transfer RNAs are adaptor molecules, which decode mRNA into protein and,<br/>thereby, play a central role in gene expression. During the maturation of a primary<br/>tRNA transcript, specific subsets of the four normal nucleosides adenosine,<br/>cytidine, guanosine, and uridine are modified. The formation of a modified nucleoside<br/>can require more than one gene product and may involve several enzymatic<br/>steps. In the last few years, the identification of gene products required for<br/>formation of modified nucleosides in tRNA has dramatically increased. In this review,<br/>proteins involved in modification of cytoplasmic tRNAs in Saccharomyces<br/>cerevisiae are described, emphasizing phenotypic characteristics of modification<br/>deficient strains and genetic approaches used to determine the in vivo role of<br/>modified nucleosides/ modifying enzymes.}}, author = {{Johansson, Marcus J.O. and Byström, Anders S.}}, booktitle = {{Fine-Tuning of RNA Functions by Modification and Editing}}, editor = {{Grosjean, Henri}}, isbn = {{978-3-540-31454-7}}, issn = {{1610-2096}}, language = {{eng}}, month = {{01}}, pages = {{87--120}}, series = {{Topics in Current Genetics}}, title = {{Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae}}, url = {{http://dx.doi.org/10.1007/b105814}}, doi = {{10.1007/b105814}}, volume = {{12}}, year = {{2005}}, }