Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study
(2012) In Haematologica 97(6). p.854-858- Abstract
- No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and... (More)
- No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P < 0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenstrom macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3001762
- author
- Kristinsson, Sigurdur Y. ; Tang, Min ; Pfeiffer, Ruth M. ; Bjorkholm, Magnus ; Goldin, Lynn R. ; Blimark, Cecilie ; Mellqvist, Ulf-Henrik ; Wahlin, Anders ; Turesson, Ingemar LU and Landgren, Ola
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- monoclonal gammopathy of undetermined significance, infections, multiple, myeloma, bacteria, virus
- in
- Haematologica
- volume
- 97
- issue
- 6
- pages
- 854 - 858
- publisher
- Ferrata Storti Foundation
- external identifiers
-
- wos:000306066500014
- scopus:84862146052
- pmid:22180421
- ISSN
- 1592-8721
- DOI
- 10.3324/haematol.2011.054015
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- 450cf23c-4daa-4d3b-b8a5-cdbb707bdf55 (old id 3001762)
- date added to LUP
- 2016-04-01 14:15:20
- date last changed
- 2022-04-06 17:39:06
@article{450cf23c-4daa-4d3b-b8a5-cdbb707bdf55,
abstract = {{No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P < 0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenstrom macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications.}},
author = {{Kristinsson, Sigurdur Y. and Tang, Min and Pfeiffer, Ruth M. and Bjorkholm, Magnus and Goldin, Lynn R. and Blimark, Cecilie and Mellqvist, Ulf-Henrik and Wahlin, Anders and Turesson, Ingemar and Landgren, Ola}},
issn = {{1592-8721}},
keywords = {{monoclonal gammopathy of undetermined significance; infections; multiple; myeloma; bacteria; virus}},
language = {{eng}},
number = {{6}},
pages = {{854--858}},
publisher = {{Ferrata Storti Foundation}},
series = {{Haematologica}},
title = {{Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study}},
url = {{http://dx.doi.org/10.3324/haematol.2011.054015}},
doi = {{10.3324/haematol.2011.054015}},
volume = {{97}},
year = {{2012}},
}