Oral provocation of patients allergic to sesquiterpene lactones with German chamomile tea to demonstrate possible systemic allergic dermatitis
(2020) In Contact Dermatitis 83(1). p.8-18- Abstract
Background: Most patients with contact allergy to Asteraceae plants are patch test positive to sesquiterpene lactone mix (SLM). There are several reports among these patients of a flare-up of hand eczema after ingestion of food and beverages originating from Asteraceae plants. Aim: To investigate whether German chamomile tea can elicit systemic allergic dermatitis. Patients and Methods: Individuals with or without contact allergy to SLM were patch tested with an extract of German chamomile tea. Six weeks later, they were provoked with capsules containing either freeze-dried German chamomile tea or placebo capsules containing lactose, in a double-blind, randomized study. A numerical rating scale (NRS) was used to ascertain the... (More)
Background: Most patients with contact allergy to Asteraceae plants are patch test positive to sesquiterpene lactone mix (SLM). There are several reports among these patients of a flare-up of hand eczema after ingestion of food and beverages originating from Asteraceae plants. Aim: To investigate whether German chamomile tea can elicit systemic allergic dermatitis. Patients and Methods: Individuals with or without contact allergy to SLM were patch tested with an extract of German chamomile tea. Six weeks later, they were provoked with capsules containing either freeze-dried German chamomile tea or placebo capsules containing lactose, in a double-blind, randomized study. A numerical rating scale (NRS) was used to ascertain the volunteers' opinion of their hand eczema status. The study individuals were examined to detect a possible flare-up of healed patch test reactions to chamomile. Results: None of the subjects had a flare-up of healed patch test reactions. According to the NRS, SLM-positive individuals experienced a significant worsening of hand eczema, independently of whether they received chamomile or lactose capsules. Conclusion: No evidence suggestive of systemic allergic dermatitis was found.
(Less)
- author
- Lundh, Kerstin LU ; Gruvberger, Birgitta LU ; Persson, Lena LU ; Hindsén, Monica LU ; Zimerson, Erik LU ; Svensson, Åke LU and Bruze, Magnus LU
- organization
- publishing date
- 2020-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Asteraceae, Compositae, contact allergy, delayed hypersensitivity, flare-up, patch testing, pompholyx, sesquiterpene lactone mix, systemic allergic dermatitis, vesicular hand eczema
- in
- Contact Dermatitis
- volume
- 83
- issue
- 1
- pages
- 11 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85083491009
- pmid:32087031
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.13499
- language
- English
- LU publication?
- yes
- id
- 4510a8f5-72bf-4ac6-9557-6cee1322da33
- date added to LUP
- 2020-05-07 16:01:43
- date last changed
- 2024-05-01 10:18:21
@article{4510a8f5-72bf-4ac6-9557-6cee1322da33,
abstract = {{<p>Background: Most patients with contact allergy to Asteraceae plants are patch test positive to sesquiterpene lactone mix (SLM). There are several reports among these patients of a flare-up of hand eczema after ingestion of food and beverages originating from Asteraceae plants. Aim: To investigate whether German chamomile tea can elicit systemic allergic dermatitis. Patients and Methods: Individuals with or without contact allergy to SLM were patch tested with an extract of German chamomile tea. Six weeks later, they were provoked with capsules containing either freeze-dried German chamomile tea or placebo capsules containing lactose, in a double-blind, randomized study. A numerical rating scale (NRS) was used to ascertain the volunteers' opinion of their hand eczema status. The study individuals were examined to detect a possible flare-up of healed patch test reactions to chamomile. Results: None of the subjects had a flare-up of healed patch test reactions. According to the NRS, SLM-positive individuals experienced a significant worsening of hand eczema, independently of whether they received chamomile or lactose capsules. Conclusion: No evidence suggestive of systemic allergic dermatitis was found.</p>}},
author = {{Lundh, Kerstin and Gruvberger, Birgitta and Persson, Lena and Hindsén, Monica and Zimerson, Erik and Svensson, Åke and Bruze, Magnus}},
issn = {{0105-1873}},
keywords = {{Asteraceae; Compositae; contact allergy; delayed hypersensitivity; flare-up; patch testing; pompholyx; sesquiterpene lactone mix; systemic allergic dermatitis; vesicular hand eczema}},
language = {{eng}},
number = {{1}},
pages = {{8--18}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Oral provocation of patients allergic to sesquiterpene lactones with German chamomile tea to demonstrate possible systemic allergic dermatitis}},
url = {{http://dx.doi.org/10.1111/cod.13499}},
doi = {{10.1111/cod.13499}},
volume = {{83}},
year = {{2020}},
}