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Self-assessed remission rates after electroconvulsive therapy of depressive disorders

Brus, O.; Cao, Y.; Gustafsson, E.; Hultén, Magnus; Landen, M.; Lundberg, J.; Nordanskog, P. LU and Nordenskjöld, Agneta (2017) In European Psychiatry 45. p.154-160
Abstract

Background Electroconvulsive therapy (ECT) effectively treats severe depression, but not all patients remit. The aim of the study was to identify clinical factors that associate with ECT-induced remission in a community setting. Methods Depressed patients who underwent ECT in 2011–2014 were identified from the Swedish National Quality Register for ECT. Remission was defined as self-rated Montgomery-Åsberg Depression Rating Scale scores of 0–10 after ECT. Other registers provided data on previous antidepressant use, comorbidities, and demographics. Results Of 1671 patients fulfilling the inclusion criteria, 42.8% achieved remission. Older age, education length over 9 years, psychotic symptoms, shorter duration of preceding antidepressant... (More)

Background Electroconvulsive therapy (ECT) effectively treats severe depression, but not all patients remit. The aim of the study was to identify clinical factors that associate with ECT-induced remission in a community setting. Methods Depressed patients who underwent ECT in 2011–2014 were identified from the Swedish National Quality Register for ECT. Remission was defined as self-rated Montgomery-Åsberg Depression Rating Scale scores of 0–10 after ECT. Other registers provided data on previous antidepressant use, comorbidities, and demographics. Results Of 1671 patients fulfilling the inclusion criteria, 42.8% achieved remission. Older age, education length over 9 years, psychotic symptoms, shorter duration of preceding antidepressant use, pulse width stimulus ≥ 0.50 ms, absence of substance use disorders, anxiety diagnosis, lamotrigine, and benzodiazepines, were associated with remission. Conclusions This study shows that psychotic subtype of depression and older age are clinically relevant predictors of a beneficial ECT effect. Additionally, ECT outcomes can be further improved by optimizing the treatment technique and concomitant medication.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ECT, Mania and bipolar disorder, Unipolar depression
in
European Psychiatry
volume
45
pages
7 pages
publisher
Elsevier Masson SAS
external identifiers
  • scopus:85028504905
  • wos:000414461300021
ISSN
0924-9338
DOI
10.1016/j.eurpsy.2017.06.015
language
English
LU publication?
no
id
4516233e-5bcf-4d63-9dab-154686163d69
date added to LUP
2017-10-05 15:23:19
date last changed
2018-01-16 13:21:07
@article{4516233e-5bcf-4d63-9dab-154686163d69,
  abstract     = {<p>Background Electroconvulsive therapy (ECT) effectively treats severe depression, but not all patients remit. The aim of the study was to identify clinical factors that associate with ECT-induced remission in a community setting. Methods Depressed patients who underwent ECT in 2011–2014 were identified from the Swedish National Quality Register for ECT. Remission was defined as self-rated Montgomery-Åsberg Depression Rating Scale scores of 0–10 after ECT. Other registers provided data on previous antidepressant use, comorbidities, and demographics. Results Of 1671 patients fulfilling the inclusion criteria, 42.8% achieved remission. Older age, education length over 9 years, psychotic symptoms, shorter duration of preceding antidepressant use, pulse width stimulus ≥ 0.50 ms, absence of substance use disorders, anxiety diagnosis, lamotrigine, and benzodiazepines, were associated with remission. Conclusions This study shows that psychotic subtype of depression and older age are clinically relevant predictors of a beneficial ECT effect. Additionally, ECT outcomes can be further improved by optimizing the treatment technique and concomitant medication.</p>},
  author       = {Brus, O. and Cao, Y. and Gustafsson, E. and Hultén, Magnus and Landen, M. and Lundberg, J. and Nordanskog, P. and Nordenskjöld, Agneta},
  issn         = {0924-9338},
  keyword      = {ECT,Mania and bipolar disorder,Unipolar depression},
  language     = {eng},
  month        = {09},
  pages        = {154--160},
  publisher    = {Elsevier Masson SAS},
  series       = {European Psychiatry},
  title        = {Self-assessed remission rates after electroconvulsive therapy of depressive disorders},
  url          = {http://dx.doi.org/10.1016/j.eurpsy.2017.06.015},
  volume       = {45},
  year         = {2017},
}