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Multiple spinal pathways mediate cutaneous nociceptive C-fibre input to the primary somatosensory cortex (SI) in the rat.

Kalliomäki, Jarkko ; Weng, Han Rong ; Nilsson, Hans Jörgen LU ; Yu, Yong Bei and Schouenborg, Jens LU (1993) In Brain Research 622(1-2). p.271-279
Abstract

In the present study, partial lesions of the lower thoracic spinal cord in rats anaesthetized with halothane and nitrous oxide were made in order to elucidate which of the spinal funiculi mediate a nociceptive C fibre input to SI. Field potentials evoked by noxious CO2-laser stimulation were recorded in the left SI. Nociceptive C fibre input from the right hindpaw to SI was propagated by the dorsal funiculi (DF) and the left and right lateral funiculi (LLF and RLF, respectively). Nociceptive C fibre input from the left hindpaw was propagated by LLF and RLF, but not DF. Input from the hindpaws mediated by LLF and RLF caused widespread surface positive potentials throughout most of SI, although potentials in the hindlimb area... (More)

In the present study, partial lesions of the lower thoracic spinal cord in rats anaesthetized with halothane and nitrous oxide were made in order to elucidate which of the spinal funiculi mediate a nociceptive C fibre input to SI. Field potentials evoked by noxious CO2-laser stimulation were recorded in the left SI. Nociceptive C fibre input from the right hindpaw to SI was propagated by the dorsal funiculi (DF) and the left and right lateral funiculi (LLF and RLF, respectively). Nociceptive C fibre input from the left hindpaw was propagated by LLF and RLF, but not DF. Input from the hindpaws mediated by LLF and RLF caused widespread surface positive potentials throughout most of SI, although potentials in the hindlimb area tended to be larger than those in other areas of SI. Input from the right hindpaw mediated by DF caused surface positive potentials mainly in the hindlimb area of SI. Intracortically, the field potentials reversed polarity in the superficial laminae and had maximal negative amplitudes in laminae III-IV (input transferred by DF and LLF) and in laminae V-VI (input transferred by LLF and RLF). It is concluded that there are multiple spinal pathways which can transfer information from cutaneous nociceptive C fibres to SI in the rat. These ascending pathways seem to activate partly different thalamo-cortical systems.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebral cortex, CO-laser, Evoked potential, Nociception, Pain, Somatosensory pathway
in
Brain Research
volume
622
issue
1-2
pages
271 - 279
publisher
Elsevier
external identifiers
  • scopus:0027293361
  • pmid:8242366
  • scopus:0027293361
ISSN
1872-6240
DOI
10.1016/0006-8993(93)90828-B
language
English
LU publication?
yes
id
451879d6-b08b-41e1-a257-eb2cf345ca2f
date added to LUP
2019-06-24 16:22:04
date last changed
2020-01-13 02:06:06
@article{451879d6-b08b-41e1-a257-eb2cf345ca2f,
  abstract     = {<p>In the present study, partial lesions of the lower thoracic spinal cord in rats anaesthetized with halothane and nitrous oxide were made in order to elucidate which of the spinal funiculi mediate a nociceptive C fibre input to SI. Field potentials evoked by noxious CO<sub>2</sub>-laser stimulation were recorded in the left SI. Nociceptive C fibre input from the right hindpaw to SI was propagated by the dorsal funiculi (DF) and the left and right lateral funiculi (LLF and RLF, respectively). Nociceptive C fibre input from the left hindpaw was propagated by LLF and RLF, but not DF. Input from the hindpaws mediated by LLF and RLF caused widespread surface positive potentials throughout most of SI, although potentials in the hindlimb area tended to be larger than those in other areas of SI. Input from the right hindpaw mediated by DF caused surface positive potentials mainly in the hindlimb area of SI. Intracortically, the field potentials reversed polarity in the superficial laminae and had maximal negative amplitudes in laminae III-IV (input transferred by DF and LLF) and in laminae V-VI (input transferred by LLF and RLF). It is concluded that there are multiple spinal pathways which can transfer information from cutaneous nociceptive C fibres to SI in the rat. These ascending pathways seem to activate partly different thalamo-cortical systems.</p>},
  author       = {Kalliomäki, Jarkko and Weng, Han Rong and Nilsson, Hans Jörgen and Yu, Yong Bei and Schouenborg, Jens},
  issn         = {1872-6240},
  language     = {eng},
  number       = {1-2},
  pages        = {271--279},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {Multiple spinal pathways mediate cutaneous nociceptive C-fibre input to the primary somatosensory cortex (SI) in the rat.},
  url          = {http://dx.doi.org/10.1016/0006-8993(93)90828-B},
  doi          = {10.1016/0006-8993(93)90828-B},
  volume       = {622},
  year         = {1993},
}