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Saccharomyces cerevisiae: a potential host for carboxylic acid production from lignocellulosic feedstock?

Sandström, Anders LU ; Almqvist, Henrik LU ; Nunes, Diogo JP LU ; Neves, Dário; Lidén, Gunnar LU and Gorwa-Grauslund, Marie-Francoise LU (2014) In Applied Microbiology and Biotechnology 98(17). p.7299-7318
Abstract
Carboxylic acids are important bulk chemicals that can be used as building blocks for the production of polymers, as acidulants, preservatives and flavour compound or as precursors for the synthesis of pharmaceuticals. Today, their production mainly takes place through catalytic processing of petroleum-based precursors. An appealing alternative would be to produce these compounds from renewable resources, using tailor-made microorganisms. Saccharomyces cerevisiae has already demonstrated its value for bioethanol production from renewable resources. In this review, we discuss Saccharomyces cerevisiae engineering potential, current strategies for carboxylic acid production as well as the specific challenges linked to the use of... (More)
Carboxylic acids are important bulk chemicals that can be used as building blocks for the production of polymers, as acidulants, preservatives and flavour compound or as precursors for the synthesis of pharmaceuticals. Today, their production mainly takes place through catalytic processing of petroleum-based precursors. An appealing alternative would be to produce these compounds from renewable resources, using tailor-made microorganisms. Saccharomyces cerevisiae has already demonstrated its value for bioethanol production from renewable resources. In this review, we discuss Saccharomyces cerevisiae engineering potential, current strategies for carboxylic acid production as well as the specific challenges linked to the use of lignocellulosic biomass as carbon source. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Microbiology and Biotechnology
volume
98
issue
17
pages
7299 - 7318
publisher
Springer
external identifiers
  • pmid:24970456
  • wos:000340837600002
  • scopus:84906948968
ISSN
1432-0614
DOI
10.1007/s00253-014-5866-5
language
English
LU publication?
yes
id
2f1f911a-be78-4223-8815-6ba73207cda8 (old id 4526700)
date added to LUP
2014-07-25 09:51:17
date last changed
2017-06-11 03:18:24
@article{2f1f911a-be78-4223-8815-6ba73207cda8,
  abstract     = {Carboxylic acids are important bulk chemicals that can be used as building blocks for the production of polymers, as acidulants, preservatives and flavour compound or as precursors for the synthesis of pharmaceuticals. Today, their production mainly takes place through catalytic processing of petroleum-based precursors. An appealing alternative would be to produce these compounds from renewable resources, using tailor-made microorganisms. Saccharomyces cerevisiae has already demonstrated its value for bioethanol production from renewable resources. In this review, we discuss Saccharomyces cerevisiae engineering potential, current strategies for carboxylic acid production as well as the specific challenges linked to the use of lignocellulosic biomass as carbon source.},
  author       = {Sandström, Anders and Almqvist, Henrik and Nunes, Diogo JP and Neves, Dário and Lidén, Gunnar and Gorwa-Grauslund, Marie-Francoise},
  issn         = {1432-0614},
  language     = {eng},
  number       = {17},
  pages        = {7299--7318},
  publisher    = {Springer},
  series       = {Applied Microbiology and Biotechnology},
  title        = {Saccharomyces cerevisiae: a potential host for carboxylic acid production from lignocellulosic feedstock?},
  url          = {http://dx.doi.org/10.1007/s00253-014-5866-5},
  volume       = {98},
  year         = {2014},
}