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A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings.

Källstrand, Johan; Lewander, Tommy; Baghdassarian, Eva and Nielzén, Sören LU (2014) In Neuropsychiatric Disease and Treatment 10(Jun 6). p.1011-1016
Abstract
The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I-VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients... (More)
The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I-VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients with schizophrenia versus patients with adult attention deficit/hyperactivity disorder versus healthy controls. The findings show promise regarding the possibility to identify ABR markers to be used as biomarkers as support for clinical diagnoses of these and other neuropsychiatric disorders. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuropsychiatric Disease and Treatment
volume
10
issue
Jun 6
pages
1011 - 1016
publisher
Dove Press
external identifiers
  • pmid:24944514
  • wos:000338346100007
  • scopus:84902327348
ISSN
1176-6328
DOI
10.2147/NDT.S59178
language
English
LU publication?
yes
id
8bb8dc4d-3dde-4c2d-a1a2-f3136d22bfdf (old id 4527961)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24944514?dopt=Abstract
date added to LUP
2014-07-06 19:15:57
date last changed
2017-07-23 03:07:48
@article{8bb8dc4d-3dde-4c2d-a1a2-f3136d22bfdf,
  abstract     = {The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I-VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients with schizophrenia versus patients with adult attention deficit/hyperactivity disorder versus healthy controls. The findings show promise regarding the possibility to identify ABR markers to be used as biomarkers as support for clinical diagnoses of these and other neuropsychiatric disorders.},
  author       = {Källstrand, Johan and Lewander, Tommy and Baghdassarian, Eva and Nielzén, Sören},
  issn         = {1176-6328},
  language     = {eng},
  number       = {Jun 6},
  pages        = {1011--1016},
  publisher    = {Dove Press},
  series       = {Neuropsychiatric Disease and Treatment},
  title        = {A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings.},
  url          = {http://dx.doi.org/10.2147/NDT.S59178},
  volume       = {10},
  year         = {2014},
}