A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings.
(2014) In Neuropsychiatric Disease and Treatment 10(Jun 6). p.1011-1016- Abstract
- The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I-VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients... (More)
- The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I-VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients with schizophrenia versus patients with adult attention deficit/hyperactivity disorder versus healthy controls. The findings show promise regarding the possibility to identify ABR markers to be used as biomarkers as support for clinical diagnoses of these and other neuropsychiatric disorders. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4527961
- author
- Källstrand, Johan ; Lewander, Tommy ; Baghdassarian, Eva and Nielzén, Sören LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuropsychiatric Disease and Treatment
- volume
- 10
- issue
- Jun 6
- pages
- 1011 - 1016
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:24944514
- wos:000338346100007
- scopus:84902327348
- pmid:24944514
- ISSN
- 1176-6328
- DOI
- 10.2147/NDT.S59178
- language
- English
- LU publication?
- yes
- id
- 8bb8dc4d-3dde-4c2d-a1a2-f3136d22bfdf (old id 4527961)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24944514?dopt=Abstract
- date added to LUP
- 2016-04-01 10:07:00
- date last changed
- 2022-04-12 02:05:56
@article{8bb8dc4d-3dde-4c2d-a1a2-f3136d22bfdf,
abstract = {{The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I-VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and sloped, making wave latencies and wave amplitudes difficult to establish. In the present paper, we describe a method, labeled moving-minimum subtraction, based on digitization of the analog ABR waveform (154 data points/ms) in order to achieve alignment of the ABR response to a straight baseline, often with clear baseline separation of waves and resolution of fused waves. Application of the new method to groups of patients showed marked differences in ABR waveforms between patients with schizophrenia versus patients with adult attention deficit/hyperactivity disorder versus healthy controls. The findings show promise regarding the possibility to identify ABR markers to be used as biomarkers as support for clinical diagnoses of these and other neuropsychiatric disorders.}},
author = {{Källstrand, Johan and Lewander, Tommy and Baghdassarian, Eva and Nielzén, Sören}},
issn = {{1176-6328}},
language = {{eng}},
number = {{Jun 6}},
pages = {{1011--1016}},
publisher = {{Dove Medical Press Ltd.}},
series = {{Neuropsychiatric Disease and Treatment}},
title = {{A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings.}},
url = {{https://lup.lub.lu.se/search/files/1574656/5152519}},
doi = {{10.2147/NDT.S59178}},
volume = {{10}},
year = {{2014}},
}