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Home treatment of patients with small to medium sized acute pulmonary embolism.

Elf, Johan LU ; Jögi, Jonas LU and Bajc, Marika LU (2015) In Journal of Thrombosis and Thrombolysis 39(2). p.166-172
Abstract
Most patients with acute pulmonary embolism (PE) are still treated as inpatients. This is a retrospective cohort study of patients with acute PE, diagnosed using V/P SPECT between 2007 and 2011. Patients were treated at home if they were hemodynamically stable, did not require oxygen or parenteral analgetics, had no contraindications to anticoagulant treatment and V/P SPECT showed an extension of the PE of less than 40 %. The aim of the study was to evaluate the efficacy and safety of home treatment with our algorithm. During the study period 416 outpatients were diagnosed with acute symptomatic PE of whom in total 260 (62.5 %) were discharged home from the emergency unit and another 47 (11 %) within 24 h from admission. During 3 months... (More)
Most patients with acute pulmonary embolism (PE) are still treated as inpatients. This is a retrospective cohort study of patients with acute PE, diagnosed using V/P SPECT between 2007 and 2011. Patients were treated at home if they were hemodynamically stable, did not require oxygen or parenteral analgetics, had no contraindications to anticoagulant treatment and V/P SPECT showed an extension of the PE of less than 40 %. The aim of the study was to evaluate the efficacy and safety of home treatment with our algorithm. During the study period 416 outpatients were diagnosed with acute symptomatic PE of whom in total 260 (62.5 %) were discharged home from the emergency unit and another 47 (11 %) within 24 h from admission. During 3 months follow-up one (0.3 %) patient had a recurrent thrombotic event. Eleven (3.6 %) patients had a major or clinically relevant bleed and the overall mortality was 2 % (n = 6). There were no PE-related mortality. Home treatment should be considered and is safe in the majority of hemodynamically stable outpatients with small to medium size PE, quantified using V/P SPECT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Thrombosis and Thrombolysis
volume
39
issue
2
pages
166 - 172
publisher
Springer
external identifiers
  • pmid:24942995
  • wos:000349528100003
  • scopus:84939885117
ISSN
1573-742X
DOI
10.1007/s11239-014-1097-y
language
English
LU publication?
yes
id
e9225d09-940a-4775-9f4d-0e980c5be34b (old id 4528192)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24942995?dopt=Abstract
date added to LUP
2014-07-06 18:54:00
date last changed
2017-06-25 03:08:21
@article{e9225d09-940a-4775-9f4d-0e980c5be34b,
  abstract     = {Most patients with acute pulmonary embolism (PE) are still treated as inpatients. This is a retrospective cohort study of patients with acute PE, diagnosed using V/P SPECT between 2007 and 2011. Patients were treated at home if they were hemodynamically stable, did not require oxygen or parenteral analgetics, had no contraindications to anticoagulant treatment and V/P SPECT showed an extension of the PE of less than 40 %. The aim of the study was to evaluate the efficacy and safety of home treatment with our algorithm. During the study period 416 outpatients were diagnosed with acute symptomatic PE of whom in total 260 (62.5 %) were discharged home from the emergency unit and another 47 (11 %) within 24 h from admission. During 3 months follow-up one (0.3 %) patient had a recurrent thrombotic event. Eleven (3.6 %) patients had a major or clinically relevant bleed and the overall mortality was 2 % (n = 6). There were no PE-related mortality. Home treatment should be considered and is safe in the majority of hemodynamically stable outpatients with small to medium size PE, quantified using V/P SPECT.},
  author       = {Elf, Johan and Jögi, Jonas and Bajc, Marika},
  issn         = {1573-742X},
  language     = {eng},
  number       = {2},
  pages        = {166--172},
  publisher    = {Springer},
  series       = {Journal of Thrombosis and Thrombolysis},
  title        = {Home treatment of patients with small to medium sized acute pulmonary embolism.},
  url          = {http://dx.doi.org/10.1007/s11239-014-1097-y},
  volume       = {39},
  year         = {2015},
}