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Tomato Thymidine Kinase Is Subject to Inefficient TTP Feedback Regulation.

Larsen, N B; Munch-Petersen, B and Piskur, Jure LU (2014) In Nucleosides, Nucleotides & Nucleic Acids 33(4-6). p.287-290
Abstract
A promising suicide gene therapy system to treat gliomas has been reported: the thymidine kinase 1 from tomato (toTK1) combined with the nucleoside analog pro-drug zidovudine (azidothymidine, AZT), which is known to penetrate the blood-brain barrier. Transduction with toTK1 has been found to efficiently increase the sensitivity of human glioblastoma cells to AZT, and nude rats with intracranial glioblastoma grafts have shown significantly improved survival when treated with the toTK1/AZT system. We show in our paper that the strong suicidal effect of AZT together with toTK1 may be explained by reduced TTP-mediated feedback inhibition of the AZT phosphorylation.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleosides, Nucleotides & Nucleic Acids
volume
33
issue
4-6
pages
287 - 290
publisher
Taylor & Francis
external identifiers
  • pmid:24940681
  • wos:000337939200017
  • scopus:84903167594
ISSN
1525-7770
DOI
10.1080/15257770.2013.853781
language
English
LU publication?
yes
id
f111beab-3792-4776-9632-1c170e40a7f4 (old id 4528230)
date added to LUP
2014-08-12 11:35:28
date last changed
2017-01-01 03:46:57
@article{f111beab-3792-4776-9632-1c170e40a7f4,
  abstract     = {A promising suicide gene therapy system to treat gliomas has been reported: the thymidine kinase 1 from tomato (toTK1) combined with the nucleoside analog pro-drug zidovudine (azidothymidine, AZT), which is known to penetrate the blood-brain barrier. Transduction with toTK1 has been found to efficiently increase the sensitivity of human glioblastoma cells to AZT, and nude rats with intracranial glioblastoma grafts have shown significantly improved survival when treated with the toTK1/AZT system. We show in our paper that the strong suicidal effect of AZT together with toTK1 may be explained by reduced TTP-mediated feedback inhibition of the AZT phosphorylation.},
  author       = {Larsen, N B and Munch-Petersen, B and Piskur, Jure},
  issn         = {1525-7770},
  language     = {eng},
  number       = {4-6},
  pages        = {287--290},
  publisher    = {Taylor & Francis},
  series       = {Nucleosides, Nucleotides & Nucleic Acids},
  title        = {Tomato Thymidine Kinase Is Subject to Inefficient TTP Feedback Regulation.},
  url          = {http://dx.doi.org/10.1080/15257770.2013.853781},
  volume       = {33},
  year         = {2014},
}