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A Compartmental Model of Mouse Thrombopoiesis and Erythropoiesis to Predict Bone Marrow Toxicity After Internal Irradiation.

Sas, Nicolas; Rousseau, Julie; Nguyen, Frédérique; Bellec, Elise; Larsson, Erik LU ; Becavin, Sonia; Hindorf, Cecilia LU ; Abadie, Jérôme; Chouin, Nicolas and Barbet, Jacques (2014) In Journal of Nuclear Medicine 55(8). p.1355-1360
Abstract
In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis and erythropoiesis was set up to predict the depletion of hematopoietic cells as a function of the irradiation dose delivered to BM by injected radiopharmaceuticals. All simulated kinetics were compared with experimental toxicity for several stages of differentiation of the 2 hematopoietic lineages.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
55
issue
8
pages
1355 - 1360
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:24935991
  • wos:000340022300028
  • scopus:84905482215
ISSN
0161-5505
DOI
10.2967/jnumed.113.133330
language
English
LU publication?
yes
id
352acbe5-de30-4575-b3d0-b91f2d7b3558 (old id 4528363)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24935991?dopt=Abstract
date added to LUP
2014-07-06 12:13:42
date last changed
2017-07-02 03:14:55
@article{352acbe5-de30-4575-b3d0-b91f2d7b3558,
  abstract     = {In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis and erythropoiesis was set up to predict the depletion of hematopoietic cells as a function of the irradiation dose delivered to BM by injected radiopharmaceuticals. All simulated kinetics were compared with experimental toxicity for several stages of differentiation of the 2 hematopoietic lineages.},
  author       = {Sas, Nicolas and Rousseau, Julie and Nguyen, Frédérique and Bellec, Elise and Larsson, Erik and Becavin, Sonia and Hindorf, Cecilia and Abadie, Jérôme and Chouin, Nicolas and Barbet, Jacques},
  issn         = {0161-5505},
  language     = {eng},
  number       = {8},
  pages        = {1355--1360},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {A Compartmental Model of Mouse Thrombopoiesis and Erythropoiesis to Predict Bone Marrow Toxicity After Internal Irradiation.},
  url          = {http://dx.doi.org/10.2967/jnumed.113.133330},
  volume       = {55},
  year         = {2014},
}