A Compartmental Model of Mouse Thrombopoiesis and Erythropoiesis to Predict Bone Marrow Toxicity After Internal Irradiation.
(2014) In Journal of Nuclear Medicine 55(8). p.1355-1360- Abstract
- In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis and erythropoiesis was set up to predict the depletion of hematopoietic cells as a function of the irradiation dose delivered to BM by injected radiopharmaceuticals. All simulated kinetics were compared with experimental toxicity for several stages of differentiation of the 2 hematopoietic lineages.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4528363
- author
- Sas, Nicolas ; Rousseau, Julie ; Nguyen, Frédérique ; Bellec, Elise ; Larsson, Erik LU ; Becavin, Sonia ; Hindorf, Cecilia LU ; Abadie, Jérôme ; Chouin, Nicolas and Barbet, Jacques
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Nuclear Medicine
- volume
- 55
- issue
- 8
- pages
- 1355 - 1360
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- pmid:24935991
- wos:000340022300028
- scopus:84905482215
- pmid:24935991
- ISSN
- 0161-5505
- DOI
- 10.2967/jnumed.113.133330
- language
- English
- LU publication?
- yes
- id
- 352acbe5-de30-4575-b3d0-b91f2d7b3558 (old id 4528363)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24935991?dopt=Abstract
- date added to LUP
- 2016-04-01 10:34:58
- date last changed
- 2022-01-26 00:39:27
@article{352acbe5-de30-4575-b3d0-b91f2d7b3558, abstract = {{In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis and erythropoiesis was set up to predict the depletion of hematopoietic cells as a function of the irradiation dose delivered to BM by injected radiopharmaceuticals. All simulated kinetics were compared with experimental toxicity for several stages of differentiation of the 2 hematopoietic lineages.}}, author = {{Sas, Nicolas and Rousseau, Julie and Nguyen, Frédérique and Bellec, Elise and Larsson, Erik and Becavin, Sonia and Hindorf, Cecilia and Abadie, Jérôme and Chouin, Nicolas and Barbet, Jacques}}, issn = {{0161-5505}}, language = {{eng}}, number = {{8}}, pages = {{1355--1360}}, publisher = {{Society of Nuclear Medicine}}, series = {{Journal of Nuclear Medicine}}, title = {{A Compartmental Model of Mouse Thrombopoiesis and Erythropoiesis to Predict Bone Marrow Toxicity After Internal Irradiation.}}, url = {{http://dx.doi.org/10.2967/jnumed.113.133330}}, doi = {{10.2967/jnumed.113.133330}}, volume = {{55}}, year = {{2014}}, }