Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.
(2014) In Arteriosclerosis, Thrombosis and Vascular Biology 34(9). p.2068-2077- Abstract
- Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4528684
- author
- Shang, Ming-Mei
; Talukdar, Husain A
; Hofmann, Jennifer J
; Niaudet, Colin
; Asl, Hassan Foroughi
; Jain, Rajeev K
; Rossignoli, Aranzazu
; Cedergren, Cecilia
; Silveira, Angela
; Gigante, Bruna
; Leander, Karin
; Faire, Ulf de
; Hamsten, Anders
; Ruusalepp, Arno
; Melander, Olle
LU
; Ivert, Torbjörn
; Michoel, Tom
; Schadt, Eric E
; Betsholtz, Christer
; Skogsberg, Josefin
and Björkegren, Johan L M
(Less) - organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 34
- issue
- 9
- pages
- 2068 - 2077
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:24925974
- wos:000340881600039
- scopus:84906939622
- ISSN
- 1524-4636
- DOI
- 10.1161/ATVBAHA.113.302709
- language
- English
- LU publication?
- yes
- id
- b03114d2-85a7-48e6-a918-2475eac2b172 (old id 4528684)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24925974?dopt=Abstract
- date added to LUP
- 2016-04-01 10:45:06
- date last changed
- 2024-01-07 00:20:24
@article{b03114d2-85a7-48e6-a918-2475eac2b172,
abstract = {{Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.}},
author = {{Shang, Ming-Mei and Talukdar, Husain A and Hofmann, Jennifer J and Niaudet, Colin and Asl, Hassan Foroughi and Jain, Rajeev K and Rossignoli, Aranzazu and Cedergren, Cecilia and Silveira, Angela and Gigante, Bruna and Leander, Karin and Faire, Ulf de and Hamsten, Anders and Ruusalepp, Arno and Melander, Olle and Ivert, Torbjörn and Michoel, Tom and Schadt, Eric E and Betsholtz, Christer and Skogsberg, Josefin and Björkegren, Johan L M}},
issn = {{1524-4636}},
language = {{eng}},
number = {{9}},
pages = {{2068--2077}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
title = {{Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.}},
url = {{http://dx.doi.org/10.1161/ATVBAHA.113.302709}},
doi = {{10.1161/ATVBAHA.113.302709}},
volume = {{34}},
year = {{2014}},
}