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Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.

Shang, Ming-Mei; Talukdar, Husain A; Hofmann, Jennifer J; Niaudet, Colin; Asl, Hassan Foroughi; Jain, Rajeev K; Rossignoli, Aranzazu; Cedergren, Cecilia; Silveira, Angela and Gigante, Bruna, et al. (2014) In Arteriosclerosis, Thrombosis and Vascular Biology 34(9). p.2068-2077
Abstract
Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.
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publication status
published
subject
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
34
issue
9
pages
2068 - 2077
publisher
American Heart Association
external identifiers
  • pmid:24925974
  • wos:000340881600039
  • scopus:84906939622
ISSN
1524-4636
DOI
10.1161/ATVBAHA.113.302709
language
English
LU publication?
yes
id
b03114d2-85a7-48e6-a918-2475eac2b172 (old id 4528684)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24925974?dopt=Abstract
date added to LUP
2014-07-05 17:58:54
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2017-01-01 03:52:07
@article{b03114d2-85a7-48e6-a918-2475eac2b172,
  abstract     = {Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.},
  author       = {Shang, Ming-Mei and Talukdar, Husain A and Hofmann, Jennifer J and Niaudet, Colin and Asl, Hassan Foroughi and Jain, Rajeev K and Rossignoli, Aranzazu and Cedergren, Cecilia and Silveira, Angela and Gigante, Bruna and Leander, Karin and Faire, Ulf de and Hamsten, Anders and Ruusalepp, Arno and Melander, Olle and Ivert, Torbjörn and Michoel, Tom and Schadt, Eric E and Betsholtz, Christer and Skogsberg, Josefin and Björkegren, Johan L M},
  issn         = {1524-4636},
  language     = {eng},
  number       = {9},
  pages        = {2068--2077},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.},
  url          = {http://dx.doi.org/10.1161/ATVBAHA.113.302709},
  volume       = {34},
  year         = {2014},
}