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CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.

Waldsee, Roya LU ; Eftekhari, Sajedeh LU ; Ahnstedt, Hilda LU ; Johnson, Leif LU and Edvinsson, Lars LU (2014) In Journal of Neuroinflammation 11(1).
Abstract
Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroinflammation
volume
11
issue
1
publisher
BioMed Central
external identifiers
  • pmid:24886705
  • wos:000337256300002
  • scopus:84901660518
ISSN
1742-2094
DOI
10.1186/1742-2094-11-90
language
English
LU publication?
yes
id
46cf7705-8c76-42cd-bf4b-6eee1d159ed1 (old id 4529455)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24886705?dopt=Abstract
date added to LUP
2014-07-04 12:42:24
date last changed
2017-01-22 03:50:16
@article{46cf7705-8c76-42cd-bf4b-6eee1d159ed1,
  abstract     = {Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries using organ culture as a method for inducing ischemic-like vascular wall changes.},
  articleno    = {90},
  author       = {Waldsee, Roya and Eftekhari, Sajedeh and Ahnstedt, Hilda and Johnson, Leif and Edvinsson, Lars},
  issn         = {1742-2094},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Neuroinflammation},
  title        = {CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture.},
  url          = {http://dx.doi.org/10.1186/1742-2094-11-90},
  volume       = {11},
  year         = {2014},
}