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Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.

Fava, Cristiano LU ; Ohlsson, Therese; Sjögren, Marketa LU ; Tagetti, Angela; Almgren, Peter LU ; Engström, Gunnar LU ; Nilsson, Peter LU ; Hedblad, Bo LU ; Minuz, Pietro and Melander, Olle LU (2014) In Journal of Hypertension 32(7). p.1424-1428
Abstract
A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
32
issue
7
pages
1424 - 1428
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:24879493
  • wos:000337351400012
  • scopus:84903888344
ISSN
1473-5598
DOI
10.1097/HJH.0000000000000209
language
English
LU publication?
yes
id
638c3a9c-fd6b-44cc-922f-797d1f6d0e2c (old id 4529603)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24879493?dopt=Abstract
date added to LUP
2014-07-04 11:52:59
date last changed
2017-01-01 03:07:26
@article{638c3a9c-fd6b-44cc-922f-797d1f6d0e2c,
  abstract     = {A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.},
  author       = {Fava, Cristiano and Ohlsson, Therese and Sjögren, Marketa and Tagetti, Angela and Almgren, Peter and Engström, Gunnar and Nilsson, Peter and Hedblad, Bo and Minuz, Pietro and Melander, Olle},
  issn         = {1473-5598},
  language     = {eng},
  number       = {7},
  pages        = {1424--1428},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000000209},
  volume       = {32},
  year         = {2014},
}