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Similar appearance, different mechanisms: xerosis in HIV, atopic dermatitis and ageing

Mischo, Meike; von Kobyletzki, Laura LU ; Bruendermann, Erik; Schmidt, Diedrich A.; Potthoff, Anja; Brockmeyer, Norbert H. and Havenith, Martina (2014) In Experimental Dermatology 23(6). p.446-448
Abstract
Xerosis is one of the most common dermatologic disorders occurring in the elderly and in patients with atopic dermatitis (AD) and human immunodeficiency virus (HIV) infection. Xerosis has been linked to an impaired skin barrier function of the stratum corneum. Using Raman microspectroscopy, we concentrated on deeper skin layers, viable epidermis and dermis of 47 volunteers and associated molecular alterations to the evolution of xerosis and the skin barrier, for example, lipid, water and antioxidant content. A decrease in lipids within the viable epidermis is found for elderly and HIV-patients. Lipid and water values of AD patients and their healthy reference group are similar. Decreases in lipids and simultaneous increases in water are... (More)
Xerosis is one of the most common dermatologic disorders occurring in the elderly and in patients with atopic dermatitis (AD) and human immunodeficiency virus (HIV) infection. Xerosis has been linked to an impaired skin barrier function of the stratum corneum. Using Raman microspectroscopy, we concentrated on deeper skin layers, viable epidermis and dermis of 47 volunteers and associated molecular alterations to the evolution of xerosis and the skin barrier, for example, lipid, water and antioxidant content. A decrease in lipids within the viable epidermis is found for elderly and HIV-patients. Lipid and water values of AD patients and their healthy reference group are similar. Decreases in lipids and simultaneous increases in water are found in the dermis for HIV and AD patients in comparison to their healthy reference groups. Excessive levels of epidermal carotenoids, mainly lycopene, in HIV-patients were found potentially leading to adverse effects such as premature skin ageing. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atopic dermatitis, HIV, molecular composition, Raman, xerosis
in
Experimental Dermatology
volume
23
issue
6
pages
446 - 448
publisher
Wiley-Blackwell
external identifiers
  • wos:000337575200023
  • scopus:84901493129
ISSN
0906-6705
DOI
10.1111/exd.12425
language
English
LU publication?
yes
id
6e477211-91bf-42eb-853b-8d4c66ba6f66 (old id 4544975)
date added to LUP
2014-08-01 07:36:17
date last changed
2017-02-12 03:00:33
@article{6e477211-91bf-42eb-853b-8d4c66ba6f66,
  abstract     = {Xerosis is one of the most common dermatologic disorders occurring in the elderly and in patients with atopic dermatitis (AD) and human immunodeficiency virus (HIV) infection. Xerosis has been linked to an impaired skin barrier function of the stratum corneum. Using Raman microspectroscopy, we concentrated on deeper skin layers, viable epidermis and dermis of 47 volunteers and associated molecular alterations to the evolution of xerosis and the skin barrier, for example, lipid, water and antioxidant content. A decrease in lipids within the viable epidermis is found for elderly and HIV-patients. Lipid and water values of AD patients and their healthy reference group are similar. Decreases in lipids and simultaneous increases in water are found in the dermis for HIV and AD patients in comparison to their healthy reference groups. Excessive levels of epidermal carotenoids, mainly lycopene, in HIV-patients were found potentially leading to adverse effects such as premature skin ageing.},
  author       = {Mischo, Meike and von Kobyletzki, Laura and Bruendermann, Erik and Schmidt, Diedrich A. and Potthoff, Anja and Brockmeyer, Norbert H. and Havenith, Martina},
  issn         = {0906-6705},
  keyword      = {atopic dermatitis,HIV,molecular composition,Raman,xerosis},
  language     = {eng},
  number       = {6},
  pages        = {446--448},
  publisher    = {Wiley-Blackwell},
  series       = {Experimental Dermatology},
  title        = {Similar appearance, different mechanisms: xerosis in HIV, atopic dermatitis and ageing},
  url          = {http://dx.doi.org/10.1111/exd.12425},
  volume       = {23},
  year         = {2014},
}