Molecular Motor Transport through Hollow Nanowires
Lard, Mercy LU ; ten Siethoff, Lasse ; Generosi, Johanna LU ; Mansson, Alf and Linke, Heiner LU
(2014)
In Nano Letters
14(6).
p.3041-3046
- Abstract
- Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of... (More)
- Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into actin ordered contractile units, mimicking the muscle sarcomere. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4544997
- author
- Lard, Mercy
LU
; ten Siethoff, Lasse
; Generosi, Johanna
LU
; Mansson, Alf
and Linke, Heiner
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hollow nanowires, actin, myosin, molecular motors, motor proteins, 1D, gliding assay
- in
- Nano Letters
- volume
- 14
- issue
- 6
- pages
- 3041 - 3046
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000337337100012
- scopus:84902250949
- pmid:24874101
- ISSN
- 1530-6992
- DOI
- 10.1021/nl404714b
- language
- English
- LU publication?
- yes
- id
- 7a1e5957-8186-44c3-8be2-d94cc32f386f (old id 4544997)
- date added to LUP
- 2016-04-01 14:10:55
- date last changed
- 2023-11-13 03:52:20
@article{7a1e5957-8186-44c3-8be2-d94cc32f386f,
abstract = {{Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into actin ordered contractile units, mimicking the muscle sarcomere.}},
author = {{Lard, Mercy and ten Siethoff, Lasse and Generosi, Johanna and Mansson, Alf and Linke, Heiner}},
issn = {{1530-6992}},
keywords = {{Hollow nanowires; actin; myosin; molecular motors; motor proteins; 1D; gliding assay}},
language = {{eng}},
number = {{6}},
pages = {{3041--3046}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Nano Letters}},
title = {{Molecular Motor Transport through Hollow Nanowires}},
url = {{http://dx.doi.org/10.1021/nl404714b}},
doi = {{10.1021/nl404714b}},
volume = {{14}},
year = {{2014}},
}