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Molecular Motor Transport through Hollow Nanowires

Lard, Mercy LU ; ten Siethoff, Lasse; Generosi, Johanna LU ; Mansson, Alf and Linke, Heiner LU (2014) In Nano Letters 14(6). p.3041-3046
Abstract
Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of... (More)
Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into actin ordered contractile units, mimicking the muscle sarcomere. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hollow nanowires, actin, myosin, molecular motors, motor proteins, 1D, gliding assay
in
Nano Letters
volume
14
issue
6
pages
3041 - 3046
publisher
The American Chemical Society
external identifiers
  • wos:000337337100012
  • scopus:84902250949
ISSN
1530-6992
DOI
10.1021/nl404714b
language
English
LU publication?
yes
id
7a1e5957-8186-44c3-8be2-d94cc32f386f (old id 4544997)
date added to LUP
2014-07-16 15:42:19
date last changed
2017-01-08 04:36:27
@article{7a1e5957-8186-44c3-8be2-d94cc32f386f,
  abstract     = {Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into actin ordered contractile units, mimicking the muscle sarcomere.},
  author       = {Lard, Mercy and ten Siethoff, Lasse and Generosi, Johanna and Mansson, Alf and Linke, Heiner},
  issn         = {1530-6992},
  keyword      = {Hollow nanowires,actin,myosin,molecular motors,motor proteins,1D,gliding assay},
  language     = {eng},
  number       = {6},
  pages        = {3041--3046},
  publisher    = {The American Chemical Society},
  series       = {Nano Letters},
  title        = {Molecular Motor Transport through Hollow Nanowires},
  url          = {http://dx.doi.org/10.1021/nl404714b},
  volume       = {14},
  year         = {2014},
}