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Radiotherapy response in head and neck cancer - evaluation of the primary tumour site

Sjövall, Johanna LU ; Brun, Eva LU ; Almquist, Helen; Kjellén, Elisabeth LU and Wahlberg, Peter LU (2014) In Acta Oto-Laryngologica 134(6). p.646-651
Abstract
Conclusion: PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. Objectives: Assessment of remission at the primary site, in patients treated with organ preservation therapy with curative intent, is important to identify residual tumours requiring treatment with salvage surgery. The aim of this study was to evaluate the diagnostic accuracy of fluorodeoxyglucose positron emission tomography (FDG-PET) after radiotherapy with or without chemotherapy in assessing primary site response in patients with head and neck cancer. Methods: A total of 82 patients, with a positive baseline PET-CT scan... (More)
Conclusion: PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. Objectives: Assessment of remission at the primary site, in patients treated with organ preservation therapy with curative intent, is important to identify residual tumours requiring treatment with salvage surgery. The aim of this study was to evaluate the diagnostic accuracy of fluorodeoxyglucose positron emission tomography (FDG-PET) after radiotherapy with or without chemotherapy in assessing primary site response in patients with head and neck cancer. Methods: A total of 82 patients, with a positive baseline PET-CT scan before start of treatment, were evaluated with a PET-CT scan 6-7 weeks post-radiotherapy and with a clinical examination/endoscopy with or without biopsy 1-2 weeks later. The majority of patients had p16-positive oropharyngeal tumours. Results: Post-treatment, 77% of the patients had no visible hypermetabolism. If equivocal PET scans are regarded as positive, the sensitivity, specificity, negative (NPV) and positive predictive value (PPV) and accuracy were 100%, 78%, 100%, 6% and 78%, respectively. Eight patients suffered from relapses involving the primary site during the 9-month follow-up. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Squamous cell carcinoma, positron emission tomography, endoscopy, treatment outcome
in
Acta Oto-Laryngologica
volume
134
issue
6
pages
646 - 651
publisher
Taylor & Francis
external identifiers
  • wos:000336456700014
  • scopus:84900526677
ISSN
1651-2251
DOI
10.3109/00016489.2014.895038
language
English
LU publication?
yes
id
2f5cde26-0883-40f1-9cb4-bab088f3dc87 (old id 4558859)
date added to LUP
2014-08-01 07:40:47
date last changed
2017-01-01 05:53:45
@article{2f5cde26-0883-40f1-9cb4-bab088f3dc87,
  abstract     = {Conclusion: PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. Objectives: Assessment of remission at the primary site, in patients treated with organ preservation therapy with curative intent, is important to identify residual tumours requiring treatment with salvage surgery. The aim of this study was to evaluate the diagnostic accuracy of fluorodeoxyglucose positron emission tomography (FDG-PET) after radiotherapy with or without chemotherapy in assessing primary site response in patients with head and neck cancer. Methods: A total of 82 patients, with a positive baseline PET-CT scan before start of treatment, were evaluated with a PET-CT scan 6-7 weeks post-radiotherapy and with a clinical examination/endoscopy with or without biopsy 1-2 weeks later. The majority of patients had p16-positive oropharyngeal tumours. Results: Post-treatment, 77% of the patients had no visible hypermetabolism. If equivocal PET scans are regarded as positive, the sensitivity, specificity, negative (NPV) and positive predictive value (PPV) and accuracy were 100%, 78%, 100%, 6% and 78%, respectively. Eight patients suffered from relapses involving the primary site during the 9-month follow-up.},
  author       = {Sjövall, Johanna and Brun, Eva and Almquist, Helen and Kjellén, Elisabeth and Wahlberg, Peter},
  issn         = {1651-2251},
  keyword      = {Squamous cell carcinoma,positron emission tomography,endoscopy,treatment outcome},
  language     = {eng},
  number       = {6},
  pages        = {646--651},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Radiotherapy response in head and neck cancer - evaluation of the primary tumour site},
  url          = {http://dx.doi.org/10.3109/00016489.2014.895038},
  volume       = {134},
  year         = {2014},
}