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Determining the Association of the 5HTTLPR Polymorphism with Delusions and Hallucinations in Lewy Body Dementias

Creese, Byron; Ballard, Clive; Aarsland, Dag; Londos, Elisabet LU ; Sharp, Sally and Jones, Emma (2014) In The American Journal of Geriatric Psychiatry 22(6). p.580-586
Abstract
Objectives: To determine whether the 5HTTLPR serotonin transporter polymorphism is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD). Design: Prospective cohort study. Participants: A total of 187 individuals, recruited from centres in Norway, Sweden, and the United Kingdom were included in this study; 97 with clinically or neuropathologically diagnosed DLB/PDD and 90 cognitively normal individuals as a comparison group. Measurements: All participants with dementia underwent serial evaluation of neuropsychiatric symptoms to assess the presence of persistent delusions and hallucinations using the Columbia University Scale for Psychopathology in Alzheimer disease,... (More)
Objectives: To determine whether the 5HTTLPR serotonin transporter polymorphism is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD). Design: Prospective cohort study. Participants: A total of 187 individuals, recruited from centres in Norway, Sweden, and the United Kingdom were included in this study; 97 with clinically or neuropathologically diagnosed DLB/PDD and 90 cognitively normal individuals as a comparison group. Measurements: All participants with dementia underwent serial evaluation of neuropsychiatric symptoms to assess the presence of persistent delusions and hallucinations using the Columbia University Scale for Psychopathology in Alzheimer disease, the Neuropsychiatric Inventory, or the Present Behavioural Examination. Severity of cognitive impairment was measured using the Mini Mental State Examination (MMSE). Individuals were genotyped for the 5HTTLPR polymorphism. Results: Logistic regression demonstrated that homozygosity for the L/L genotype and lower MMSE were associated with an increased risk for delusions (odds ratio: 11.5 and 1.16, respectively). Neither was significantly associated with hallucinations. Conclusions: This study is the first to demonstrate the 5HTTLPR polymorphism is associated with delusions in Lewy body dementias, with important implications regarding the mechanisms underlying this symptom across the AD/DLB/PDD spectrum. Further studies are warranted to investigate this relationship further and examine treatment opportunities. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SLC6A4, 5HTTLPR, polymorphism, dementia with Lewy bodies, Parkinson, disease dementia, psychosis
in
The American Journal of Geriatric Psychiatry
volume
22
issue
6
pages
580 - 586
publisher
Elsevier
external identifiers
  • wos:000336087400008
  • scopus:84901634829
ISSN
1545-7214
DOI
10.1016/j.jagp.2012.11.001
language
English
LU publication?
yes
id
a47e6641-36e7-4a3f-80e7-bc9b6bfa9fd0 (old id 4558880)
date added to LUP
2014-08-01 07:41:00
date last changed
2017-08-20 03:01:23
@article{a47e6641-36e7-4a3f-80e7-bc9b6bfa9fd0,
  abstract     = {Objectives: To determine whether the 5HTTLPR serotonin transporter polymorphism is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD). Design: Prospective cohort study. Participants: A total of 187 individuals, recruited from centres in Norway, Sweden, and the United Kingdom were included in this study; 97 with clinically or neuropathologically diagnosed DLB/PDD and 90 cognitively normal individuals as a comparison group. Measurements: All participants with dementia underwent serial evaluation of neuropsychiatric symptoms to assess the presence of persistent delusions and hallucinations using the Columbia University Scale for Psychopathology in Alzheimer disease, the Neuropsychiatric Inventory, or the Present Behavioural Examination. Severity of cognitive impairment was measured using the Mini Mental State Examination (MMSE). Individuals were genotyped for the 5HTTLPR polymorphism. Results: Logistic regression demonstrated that homozygosity for the L/L genotype and lower MMSE were associated with an increased risk for delusions (odds ratio: 11.5 and 1.16, respectively). Neither was significantly associated with hallucinations. Conclusions: This study is the first to demonstrate the 5HTTLPR polymorphism is associated with delusions in Lewy body dementias, with important implications regarding the mechanisms underlying this symptom across the AD/DLB/PDD spectrum. Further studies are warranted to investigate this relationship further and examine treatment opportunities.},
  author       = {Creese, Byron and Ballard, Clive and Aarsland, Dag and Londos, Elisabet and Sharp, Sally and Jones, Emma},
  issn         = {1545-7214},
  keyword      = {SLC6A4,5HTTLPR,polymorphism,dementia with Lewy bodies,Parkinson,disease dementia,psychosis},
  language     = {eng},
  number       = {6},
  pages        = {580--586},
  publisher    = {Elsevier},
  series       = {The American Journal of Geriatric Psychiatry},
  title        = {Determining the Association of the 5HTTLPR Polymorphism with Delusions and Hallucinations in Lewy Body Dementias},
  url          = {http://dx.doi.org/10.1016/j.jagp.2012.11.001},
  volume       = {22},
  year         = {2014},
}