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Accurate T-1 Mapping for Oxygen-Enhanced MRI in the Mouse Lung Using a Segmented Inversion-Recovery Ultrashort Echo-Time Sequence

Zurek, M.; Johansson, E.; Risse, F.; Alamidi, D.; Olsson, Lars E LU and Hockings, P. D. (2014) In Magnetic Resonance in Medicine 71(6). p.2180-2185
Abstract
PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. ResultsThe simulations demonstrated the high potential of the technique for... (More)
PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. ResultsThe simulations demonstrated the high potential of the technique for accurate and precise T-1 assessment. Phantom experiments showed good agreement for T-1 values measured with segmented inversion-recovery ultrashort echo-time and the reference technique. The in vivo experiment demonstrated the utility of the technique in oxygen-enhanced assessment, where small T-1 changes were detected with high precision. ConclusionSegmented inversion-recovery ultrashort echo-time provides accurate, high resolution T-1 mapping of the lung parenchyma. Magn Reson Med 71:2180-2185, 2014. (c) 2013 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T-1 mapping, lung MRI, ultrashort echo-time, UTE, segmented inversion, recovery, oxygen-enhanced imaging, mouse
in
Magnetic Resonance in Medicine
volume
71
issue
6
pages
2180 - 2185
publisher
Wiley Online Library
external identifiers
  • wos:000336260900025
  • scopus:84900792712
ISSN
1522-2594
DOI
10.1002/mrm.24876
language
English
LU publication?
yes
id
fb615f1a-1ad6-452c-a641-451464448e18 (old id 4559017)
date added to LUP
2014-08-01 07:41:48
date last changed
2017-05-28 03:04:38
@article{fb615f1a-1ad6-452c-a641-451464448e18,
  abstract     = {PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. ResultsThe simulations demonstrated the high potential of the technique for accurate and precise T-1 assessment. Phantom experiments showed good agreement for T-1 values measured with segmented inversion-recovery ultrashort echo-time and the reference technique. The in vivo experiment demonstrated the utility of the technique in oxygen-enhanced assessment, where small T-1 changes were detected with high precision. ConclusionSegmented inversion-recovery ultrashort echo-time provides accurate, high resolution T-1 mapping of the lung parenchyma. Magn Reson Med 71:2180-2185, 2014. (c) 2013 Wiley Periodicals, Inc.},
  author       = {Zurek, M. and Johansson, E. and Risse, F. and Alamidi, D. and Olsson, Lars E and Hockings, P. D.},
  issn         = {1522-2594},
  keyword      = {T-1 mapping,lung MRI,ultrashort echo-time,UTE,segmented inversion,recovery,oxygen-enhanced imaging,mouse},
  language     = {eng},
  number       = {6},
  pages        = {2180--2185},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Accurate T-1 Mapping for Oxygen-Enhanced MRI in the Mouse Lung Using a Segmented Inversion-Recovery Ultrashort Echo-Time Sequence},
  url          = {http://dx.doi.org/10.1002/mrm.24876},
  volume       = {71},
  year         = {2014},
}