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Plasticity of Cerebrovascular Smooth Muscle Cells After Subarachnoid Hemorrhage

Edvinsson, Lars LU ; Larsen, Stine Schmidt; Maddahi, Aida LU and Nielsen, Janne (2014) In Translational Stroke Research 5(3). p.365-376
Abstract
Subarachnoid hemorrhage (SAH) is most often followed by a delayed phase of cerebral ischemia which is associated with high morbidity and mortality rates. The causes underlying this delayed phase are still unsettled, but are believed to include cerebral vasospasm, cortical spreading depression, inflammatory reactions, and microthrombosis. Additionally, a large body of evidence indicates that vascular plasticity plays an important role in SAH pathophysiology, and this review aims to summarize our current knowledge on the phenotypic changes of vascular smooth muscle cells of the cerebral vasculature following SAH. In light of the emerging view that the whole cerebral vasculature and the cells of the brain parenchyma should be viewed as one... (More)
Subarachnoid hemorrhage (SAH) is most often followed by a delayed phase of cerebral ischemia which is associated with high morbidity and mortality rates. The causes underlying this delayed phase are still unsettled, but are believed to include cerebral vasospasm, cortical spreading depression, inflammatory reactions, and microthrombosis. Additionally, a large body of evidence indicates that vascular plasticity plays an important role in SAH pathophysiology, and this review aims to summarize our current knowledge on the phenotypic changes of vascular smooth muscle cells of the cerebral vasculature following SAH. In light of the emerging view that the whole cerebral vasculature and the cells of the brain parenchyma should be viewed as one integrated neurovascular network, phenotypical changes are discussed both for the cerebral arteries and the microvasculature. Furthermore, the intracellular signaling involved in the vascular plasticity is discussed with a focus on the Raf-MEK1/2-ERK1/2 pathway which seems to play a crucial role in SAH pathology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Subarachnoid hemorrhage, Vascular plasticity, Cerebral ischemia, Cerebral arteries, Microvasculature, Vasoconstrictor receptors, Pro-inflammatory cytokines
in
Translational Stroke Research
volume
5
issue
3
pages
365 - 376
publisher
Springer
external identifiers
  • wos:000336336200007
  • scopus:84901275664
ISSN
1868-4483
DOI
10.1007/s12975-014-0331-4
language
English
LU publication?
yes
id
a0c7b579-0383-413e-a503-55c3a910e163 (old id 4559059)
date added to LUP
2014-08-01 07:42:14
date last changed
2017-10-01 03:34:18
@article{a0c7b579-0383-413e-a503-55c3a910e163,
  abstract     = {Subarachnoid hemorrhage (SAH) is most often followed by a delayed phase of cerebral ischemia which is associated with high morbidity and mortality rates. The causes underlying this delayed phase are still unsettled, but are believed to include cerebral vasospasm, cortical spreading depression, inflammatory reactions, and microthrombosis. Additionally, a large body of evidence indicates that vascular plasticity plays an important role in SAH pathophysiology, and this review aims to summarize our current knowledge on the phenotypic changes of vascular smooth muscle cells of the cerebral vasculature following SAH. In light of the emerging view that the whole cerebral vasculature and the cells of the brain parenchyma should be viewed as one integrated neurovascular network, phenotypical changes are discussed both for the cerebral arteries and the microvasculature. Furthermore, the intracellular signaling involved in the vascular plasticity is discussed with a focus on the Raf-MEK1/2-ERK1/2 pathway which seems to play a crucial role in SAH pathology.},
  author       = {Edvinsson, Lars and Larsen, Stine Schmidt and Maddahi, Aida and Nielsen, Janne},
  issn         = {1868-4483},
  keyword      = {Subarachnoid hemorrhage,Vascular plasticity,Cerebral ischemia,Cerebral arteries,Microvasculature,Vasoconstrictor receptors,Pro-inflammatory cytokines},
  language     = {eng},
  number       = {3},
  pages        = {365--376},
  publisher    = {Springer},
  series       = {Translational Stroke Research},
  title        = {Plasticity of Cerebrovascular Smooth Muscle Cells After Subarachnoid Hemorrhage},
  url          = {http://dx.doi.org/10.1007/s12975-014-0331-4},
  volume       = {5},
  year         = {2014},
}