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Equilibrium sampling through membrane based on a hollow fiber for determination of naproxen and diclofenac in sludge slurry using Taguchi orthogonal array experimental design

Ezoddin, Maryam; Jönsson, Jan Åke LU and Kyani, Anahita (2014) In Desalination and Water Treatment 52(13-15). p.2472-2480
Abstract
A three-phase hollow fiber liquid phase microextraction (HF-LPME) method was evaluated for the extraction and preconcentration of naproxen and diclofenac using a polypropylene membrane followed by analysis using HPLC or LC/MS. In this technique, the drugs were extracted into di-n-hexyl ether immobilized in the wall pores of a porous hollow fiber from 50mL of sludge slurry sample as a donor phase with pH 3, and then back-extracted into the acceptor phase located in the lumen of the hollow fiber. Experimental factors were studied in 16 trials using a Taguchi orthogonal array experimental design with an OA(16) (4(5)) matrix. The significance of these factors was investigated using analysis of variance. The extraction time was statistically... (More)
A three-phase hollow fiber liquid phase microextraction (HF-LPME) method was evaluated for the extraction and preconcentration of naproxen and diclofenac using a polypropylene membrane followed by analysis using HPLC or LC/MS. In this technique, the drugs were extracted into di-n-hexyl ether immobilized in the wall pores of a porous hollow fiber from 50mL of sludge slurry sample as a donor phase with pH 3, and then back-extracted into the acceptor phase located in the lumen of the hollow fiber. Experimental factors were studied in 16 trials using a Taguchi orthogonal array experimental design with an OA(16) (4(5)) matrix. The significance of these factors was investigated using analysis of variance. The extraction time was statistically demonstrated as the main factor for the extraction of naproxen and diclofenac, while ionic strength played the role of the second most important factor for HF-LPME extraction of diclofenac. The method permitted a detection limit of 0.2-0.7ngg(-1) with relative standard deviation values of 3-5%. Enrichment factors of 2,300 for naproxen and 1,400 for diclofenac were achieved. The method was applied to determine naproxen and diclofenac in sewage sludge from sewage treatment plant, Kallby (Lund, Sweden). (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Hollow fiber liquid phase microextraction, Taguchi orthogonal array, Diclofenac, Naproxen, Liquid chromatography-mass spectrometry
in
Desalination and Water Treatment
volume
52
issue
13-15
pages
2472 - 2480
publisher
Desalination Publications
external identifiers
  • wos:000333884400014
  • scopus:84898736301
ISSN
1944-3986
DOI
10.1080/19443994.2013.796894
language
English
LU publication?
yes
id
69700c74-8fde-45b9-9e45-cb9cedabf420 (old id 4559244)
date added to LUP
2014-07-17 15:03:11
date last changed
2017-08-20 03:21:11
@article{69700c74-8fde-45b9-9e45-cb9cedabf420,
  abstract     = {A three-phase hollow fiber liquid phase microextraction (HF-LPME) method was evaluated for the extraction and preconcentration of naproxen and diclofenac using a polypropylene membrane followed by analysis using HPLC or LC/MS. In this technique, the drugs were extracted into di-n-hexyl ether immobilized in the wall pores of a porous hollow fiber from 50mL of sludge slurry sample as a donor phase with pH 3, and then back-extracted into the acceptor phase located in the lumen of the hollow fiber. Experimental factors were studied in 16 trials using a Taguchi orthogonal array experimental design with an OA(16) (4(5)) matrix. The significance of these factors was investigated using analysis of variance. The extraction time was statistically demonstrated as the main factor for the extraction of naproxen and diclofenac, while ionic strength played the role of the second most important factor for HF-LPME extraction of diclofenac. The method permitted a detection limit of 0.2-0.7ngg(-1) with relative standard deviation values of 3-5%. Enrichment factors of 2,300 for naproxen and 1,400 for diclofenac were achieved. The method was applied to determine naproxen and diclofenac in sewage sludge from sewage treatment plant, Kallby (Lund, Sweden).},
  author       = {Ezoddin, Maryam and Jönsson, Jan Åke and Kyani, Anahita},
  issn         = {1944-3986},
  keyword      = {Hollow fiber liquid phase microextraction,Taguchi orthogonal array,Diclofenac,Naproxen,Liquid chromatography-mass spectrometry},
  language     = {eng},
  number       = {13-15},
  pages        = {2472--2480},
  publisher    = {Desalination Publications},
  series       = {Desalination and Water Treatment},
  title        = {Equilibrium sampling through membrane based on a hollow fiber for determination of naproxen and diclofenac in sludge slurry using Taguchi orthogonal array experimental design},
  url          = {http://dx.doi.org/10.1080/19443994.2013.796894},
  volume       = {52},
  year         = {2014},
}