Late neonatal lupus erythematosus onset in a child born of a mother with primary Sjogren's syndrome
(2004) In Annals of the Rheumatic Diseases 63(11). p.1496-1497- Abstract
- Background: The neonatal lupus syndrome can be present as congenital heart block (CHB) or as neonatal lupus erythematosus (NLE), both seldom passively acquired autoimmune diseases. CHB starts around week 20 of pregnancy and is a lifelong event, whereas NLE is self limiting and usually starts at the 6th week of the child's age - the maximum recorded up to week 20. Case report: An asymptomatic mother with primary Sjogren's syndrome and anti-SSA/Ro52, anti-SSA/Ro60, and anti-SSB/La autoantibodies is described who, at gestational week 23 during her first pregnancy, was diagnosed as having a male fetus with CHB due to third degree atrioventricular block. The boy from the second pregnancy developed skin eruptions which clinically and by biopsy... (More)
- Background: The neonatal lupus syndrome can be present as congenital heart block (CHB) or as neonatal lupus erythematosus (NLE), both seldom passively acquired autoimmune diseases. CHB starts around week 20 of pregnancy and is a lifelong event, whereas NLE is self limiting and usually starts at the 6th week of the child's age - the maximum recorded up to week 20. Case report: An asymptomatic mother with primary Sjogren's syndrome and anti-SSA/Ro52, anti-SSA/Ro60, and anti-SSB/La autoantibodies is described who, at gestational week 23 during her first pregnancy, was diagnosed as having a male fetus with CHB due to third degree atrioventricular block. The boy from the second pregnancy developed skin eruptions which clinically and by biopsy were compatible with NLE at week 20+1 post partum. Conclusions: Our case of NLE, starting at week 20+1 of age, seems to be the latest reported clinical case of NLE. Development of CHB and NLE in two consecutive boy pregnancies is unusual. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/898152
- author
- Manthorpe, Rolf LU ; Svensson, Åke LU and Wirestrand, LE
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of the Rheumatic Diseases
- volume
- 63
- issue
- 11
- pages
- 1496 - 1497
- publisher
- BMJ Publishing Group
- external identifiers
-
- wos:000224412800023
- pmid:15479901
- scopus:7244252965
- ISSN
- 1468-2060
- DOI
- 10.1136/ard.2003.014944
- language
- English
- LU publication?
- yes
- id
- 457037c6-10d8-477e-96ab-fbdbc345f339 (old id 898152)
- date added to LUP
- 2016-04-01 16:04:22
- date last changed
- 2022-01-28 17:06:17
@article{457037c6-10d8-477e-96ab-fbdbc345f339, abstract = {{Background: The neonatal lupus syndrome can be present as congenital heart block (CHB) or as neonatal lupus erythematosus (NLE), both seldom passively acquired autoimmune diseases. CHB starts around week 20 of pregnancy and is a lifelong event, whereas NLE is self limiting and usually starts at the 6th week of the child's age - the maximum recorded up to week 20. Case report: An asymptomatic mother with primary Sjogren's syndrome and anti-SSA/Ro52, anti-SSA/Ro60, and anti-SSB/La autoantibodies is described who, at gestational week 23 during her first pregnancy, was diagnosed as having a male fetus with CHB due to third degree atrioventricular block. The boy from the second pregnancy developed skin eruptions which clinically and by biopsy were compatible with NLE at week 20+1 post partum. Conclusions: Our case of NLE, starting at week 20+1 of age, seems to be the latest reported clinical case of NLE. Development of CHB and NLE in two consecutive boy pregnancies is unusual.}}, author = {{Manthorpe, Rolf and Svensson, Åke and Wirestrand, LE}}, issn = {{1468-2060}}, language = {{eng}}, number = {{11}}, pages = {{1496--1497}}, publisher = {{BMJ Publishing Group}}, series = {{Annals of the Rheumatic Diseases}}, title = {{Late neonatal lupus erythematosus onset in a child born of a mother with primary Sjogren's syndrome}}, url = {{http://dx.doi.org/10.1136/ard.2003.014944}}, doi = {{10.1136/ard.2003.014944}}, volume = {{63}}, year = {{2004}}, }