Prognostic and Predictive Factors in Early Alzheimer's Disease : A Systematic Review
Garcia, Maria João ; Leadley, Regina ; Ross, Janine ; Bozeat, Sasha ; Redhead, Gabrielle ; Hansson, Oskar LU
; Iwatsubo, Takeshi
; Villain, Nicolas
and Cummings, Jeffrey
(2024)
In Journal of Alzheimer's Disease Reports
8(1).
p.203-240
- Abstract
Background: Alzheimer's disease (AD) causes progressive decline of cognition and function. There is a lack of systematic literature reviews on prognostic and predictive factors in its early clinical stages (eAD), i.e., mild cognitive impairment due to AD and mild AD dementia. Objective: To identify prognostic factors affecting eAD progression and predictive factors for treatment efficacy and safety of approved and/or under late-stage development disease-modifying treatments. Methods: Databases were searched (August 2022) for studies reporting prognostic factors associated with eAD progression and predictive factors for treatment response. The Quality in Prognostic Factor Studies tool or the Cochrane risk of bias tool were used to assess... (More)
Background: Alzheimer's disease (AD) causes progressive decline of cognition and function. There is a lack of systematic literature reviews on prognostic and predictive factors in its early clinical stages (eAD), i.e., mild cognitive impairment due to AD and mild AD dementia. Objective: To identify prognostic factors affecting eAD progression and predictive factors for treatment efficacy and safety of approved and/or under late-stage development disease-modifying treatments. Methods: Databases were searched (August 2022) for studies reporting prognostic factors associated with eAD progression and predictive factors for treatment response. The Quality in Prognostic Factor Studies tool or the Cochrane risk of bias tool were used to assess risk of bias. Two reviewers independently screened the records. A single reviewer performed data extraction and quality assessment. A second performed a 20% check. Content experts reviewed and interpreted the data collected. Results: Sixty-one studies were included. Self-reporting, diagnosis definition, and missing data led to high risk of bias. Population size ranged from 110 to 11,451. Analyses found data indicating that older age was and depression may be associated with progression. Greater baseline cognitive impairment was associated with progression. APOE4 may be a prognostic factor, a predictive factor for treatment efficacy and predicts an adverse response (ARIA). Elevated biomarkers (CSF/plasma p-tau, CSF t-tau, and plasma neurofilament light) were associated with disease progression. Conclusions: Age was the strongest risk factor for progression. Biomarkers were associated with progression, supporting their use in trial selection and aiding diagnosis. Baseline cognitive impairment was a prognostic factor. APOE4 predicted ARIA, aligning with emerging evidence and relevant to treatment initiation/monitoring.
(Less)
- author
- Garcia, Maria João
; Leadley, Regina
; Ross, Janine
; Bozeat, Sasha
; Redhead, Gabrielle
; Hansson, Oskar
LU
; Iwatsubo, Takeshi
; Villain, Nicolas
and Cummings, Jeffrey
- organization
- publishing date
- 2024-02-16
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, cognitive dysfunction, prognosis, review
- in
- Journal of Alzheimer's Disease Reports
- volume
- 8
- issue
- 1
- pages
- 38 pages
- publisher
- IOS Press
- external identifiers
-
- pmid:38405341
- scopus:85185603827
- ISSN
- 2542-4823
- DOI
- 10.3233/ADR-230045
- language
- English
- LU publication?
- yes
- id
- 45779ca0-ec9a-4831-a439-40ce60e51b68
- date added to LUP
- 2024-03-20 10:34:07
- date last changed
- 2024-04-17 12:28:07
@article{45779ca0-ec9a-4831-a439-40ce60e51b68,
abstract = {{<p>Background: Alzheimer's disease (AD) causes progressive decline of cognition and function. There is a lack of systematic literature reviews on prognostic and predictive factors in its early clinical stages (eAD), i.e., mild cognitive impairment due to AD and mild AD dementia. Objective: To identify prognostic factors affecting eAD progression and predictive factors for treatment efficacy and safety of approved and/or under late-stage development disease-modifying treatments. Methods: Databases were searched (August 2022) for studies reporting prognostic factors associated with eAD progression and predictive factors for treatment response. The Quality in Prognostic Factor Studies tool or the Cochrane risk of bias tool were used to assess risk of bias. Two reviewers independently screened the records. A single reviewer performed data extraction and quality assessment. A second performed a 20% check. Content experts reviewed and interpreted the data collected. Results: Sixty-one studies were included. Self-reporting, diagnosis definition, and missing data led to high risk of bias. Population size ranged from 110 to 11,451. Analyses found data indicating that older age was and depression may be associated with progression. Greater baseline cognitive impairment was associated with progression. APOE4 may be a prognostic factor, a predictive factor for treatment efficacy and predicts an adverse response (ARIA). Elevated biomarkers (CSF/plasma p-tau, CSF t-tau, and plasma neurofilament light) were associated with disease progression. Conclusions: Age was the strongest risk factor for progression. Biomarkers were associated with progression, supporting their use in trial selection and aiding diagnosis. Baseline cognitive impairment was a prognostic factor. APOE4 predicted ARIA, aligning with emerging evidence and relevant to treatment initiation/monitoring.</p>}},
author = {{Garcia, Maria João and Leadley, Regina and Ross, Janine and Bozeat, Sasha and Redhead, Gabrielle and Hansson, Oskar and Iwatsubo, Takeshi and Villain, Nicolas and Cummings, Jeffrey}},
issn = {{2542-4823}},
keywords = {{Alzheimer's disease; cognitive dysfunction; prognosis; review}},
language = {{eng}},
month = {{02}},
number = {{1}},
pages = {{203--240}},
publisher = {{IOS Press}},
series = {{Journal of Alzheimer's Disease Reports}},
title = {{Prognostic and Predictive Factors in Early Alzheimer's Disease : A Systematic Review}},
url = {{http://dx.doi.org/10.3233/ADR-230045}},
doi = {{10.3233/ADR-230045}},
volume = {{8}},
year = {{2024}},
}