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Serum biomarkers of early stages of hypertrophic cardiomyopathy in a young population

Fernlund, Eva I. LU ; Gyllenhammar, Tom LU ; Larsson, Anders; Arnlov, Johan; Carlsson, Marcus LU ; Jablonowski, Robert LU and Liuba, Petru LU (2015) In Journal of the American College of Cardiology 65(10S). p.787-787
Abstract
Background: Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiac disorder and the leading cause of sudden cardiac death in the young. Although in a majority of HCM cases there are gene mutations coding for sarcomere proteins, the onset for the clinical consequences of these mutations are difficult to predict, as these mutations do not show any clear relationship to the degree of myocardial hypertrophy. Hence identification of early markers for this disease is important. The aim of this study was to investigate novel serum biomarkers reflecting myocardial remodeling, microfibrosis and coronary endotheliopathy in young presymtomatic HCM patients and in individuals at risk for developing HCM. Methods: Eighty-nine... (More)
Background: Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiac disorder and the leading cause of sudden cardiac death in the young. Although in a majority of HCM cases there are gene mutations coding for sarcomere proteins, the onset for the clinical consequences of these mutations are difficult to predict, as these mutations do not show any clear relationship to the degree of myocardial hypertrophy. Hence identification of early markers for this disease is important. The aim of this study was to investigate novel serum biomarkers reflecting myocardial remodeling, microfibrosis and coronary endotheliopathy in young presymtomatic HCM patients and in individuals at risk for developing HCM. Methods: Eighty-nine participants (18 HCM patients, 14 HCM-risk individuals, and 57 healthy controls) with median age of 15 (range 0-30) years underwent assessment with echocardiography and serum analysis for myostatin, cathepsin S, endostatin, type I collagen degradation marker (ICTP), matrix metalloproteinase (MMP) 9, vascular (VCAM) and intercellular adhesion molecules (ICAM). In some individuals, myocardial perfusion was measured both at rest and after adenosine via magnetic resonance. Results: Both cathepsin S and endostatin were increased in the HCM group (p0.3) and diastolic function, expressed as E/e' (p0.3). In the HCM-risk group, myostatin was decreased (p0.1). Conclusion: To the best of our knowledge, this is the first study to suggest early onset changes in biomarkers of myoblast regulation, endothelial function and matrix remodeling in young presymptomatic HCM patients and in HCM-risk individuals. (Less)
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keywords
biological marker, myostatin, endostatin, marker, cathepsin S, protein, adenosine, cell adhesion molecule, gelatinase B, serum, hypertrophic cardiomyopathy, population, American, college, cardiology, human, risk, patient, heart muscle perfusion, mutation, sarcomere, myoblast, echocardiography, heart left ventricle mass, nuclear magnetic resonance, gene mutation, sudden cardiac death, heart ventricle hypertrophy, cell adhesion, control group, high risk population, collagen degradation, diseases
in
Journal of the American College of Cardiology
volume
65
issue
10S
pages
1 pages
publisher
Elsevier USA
ISSN
0735-1097
language
English
LU publication?
yes
id
4580a0b5-31b6-482d-8467-813cf4502f13
date added to LUP
2017-07-21 10:41:40
date last changed
2017-07-25 12:36:19
@misc{4580a0b5-31b6-482d-8467-813cf4502f13,
  abstract     = {Background: Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiac disorder and the leading cause of sudden cardiac death in the young. Although in a majority of HCM cases there are gene mutations coding for sarcomere proteins, the onset for the clinical consequences of these mutations are difficult to predict, as these mutations do not show any clear relationship to the degree of myocardial hypertrophy. Hence identification of early markers for this disease is important. The aim of this study was to investigate novel serum biomarkers reflecting myocardial remodeling, microfibrosis and coronary endotheliopathy in young presymtomatic HCM patients and in individuals at risk for developing HCM. Methods: Eighty-nine participants (18 HCM patients, 14 HCM-risk individuals, and 57 healthy controls) with median age of 15 (range 0-30) years underwent assessment with echocardiography and serum analysis for myostatin, cathepsin S, endostatin, type I collagen degradation marker (ICTP), matrix metalloproteinase (MMP) 9, vascular (VCAM) and intercellular adhesion molecules (ICAM). In some individuals, myocardial perfusion was measured both at rest and after adenosine via magnetic resonance. Results: Both cathepsin S and endostatin were increased in the HCM group (p0.3) and diastolic function, expressed as E/e' (p0.3). In the HCM-risk group, myostatin was decreased (p0.1). Conclusion: To the best of our knowledge, this is the first study to suggest early onset changes in biomarkers of myoblast regulation, endothelial function and matrix remodeling in young presymptomatic HCM patients and in HCM-risk individuals.},
  author       = {Fernlund, Eva I. and Gyllenhammar, Tom and Larsson, Anders and Arnlov, Johan and Carlsson, Marcus and Jablonowski, Robert and Liuba, Petru},
  issn         = {0735-1097},
  keyword      = {biological marker,myostatin,endostatin,marker,cathepsin S,protein,adenosine,cell adhesion molecule,gelatinase B,serum,hypertrophic cardiomyopathy,population,American,college,cardiology,human,risk,patient,heart muscle perfusion,mutation,sarcomere,myoblast,echocardiography,heart left ventricle mass,nuclear magnetic resonance,gene mutation,sudden cardiac death,heart ventricle hypertrophy,cell adhesion,control group,high risk population,collagen degradation,diseases},
  language     = {eng},
  month        = {03},
  note         = {Conference Abstract},
  number       = {10S},
  pages        = {787--787},
  publisher    = {Elsevier USA},
  series       = {Journal of the American College of Cardiology},
  title        = {Serum biomarkers of early stages of hypertrophic cardiomyopathy in a young population},
  volume       = {65},
  year         = {2015},
}