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Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Danielsen, Stine A; Lind, Guro E; Kolberg, Matthias; Høland, Maren; Bjerkehagen, Bodil; Sundby Hall, Kirsten; van den Berg, Eva; Mertens, Fredrik LU ; Smeland, Sigbjørn and Picci, Piero, et al. (2015) In Neuro-Oncology 17(1). p.63-69
Abstract
Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.
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type
Contribution to journal
publication status
published
subject
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Neuro-Oncology
volume
17
issue
1
pages
63 - 69
publisher
Oxford University Press
external identifiers
  • pmid:25038505
  • wos:000350138000008
  • scopus:84922572928
ISSN
1523-5866
DOI
10.1093/neuonc/nou140
language
English
LU publication?
yes
id
d55f9678-30ec-4c72-8c5a-e0cd07230499 (old id 4581914)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25038505?dopt=Abstract
date added to LUP
2014-09-09 19:45:54
date last changed
2017-09-17 04:20:55
@article{d55f9678-30ec-4c72-8c5a-e0cd07230499,
  abstract     = {Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.},
  author       = {Danielsen, Stine A and Lind, Guro E and Kolberg, Matthias and Høland, Maren and Bjerkehagen, Bodil and Sundby Hall, Kirsten and van den Berg, Eva and Mertens, Fredrik and Smeland, Sigbjørn and Picci, Piero and Lothe, Ragnhild A},
  issn         = {1523-5866},
  language     = {eng},
  number       = {1},
  pages        = {63--69},
  publisher    = {Oxford University Press},
  series       = {Neuro-Oncology},
  title        = {Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.},
  url          = {http://dx.doi.org/10.1093/neuonc/nou140},
  volume       = {17},
  year         = {2015},
}