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Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial.

Zanchetti, Alberto; Liu, Lisheng; Mancia, Giuseppe; Parati, Gianfranco; Grassi, Guido; Stramba-Badiale, Marco; Silani, Vincenzo; Bilo, Grzegorz; Corrao, Giovanni and Zambon, Antonella, et al. (2014) In Journal of Hypertension 32(9). p.1888-1897
Abstract
The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level... (More)
The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design. (Less)
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Contribution to journal
publication status
published
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in
Journal of Hypertension
volume
32
issue
9
pages
1888 - 1897
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:24979303
  • wos:000340561200021
  • scopus:84906089553
ISSN
1473-5598
DOI
10.1097/HJH.0000000000000254
language
English
LU publication?
yes
id
3a2906a0-d362-4076-80d0-6dbdb3eb9d3e (old id 4583842)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24979303?dopt=Abstract
date added to LUP
2014-08-06 21:27:00
date last changed
2017-10-22 03:04:23
@article{3a2906a0-d362-4076-80d0-6dbdb3eb9d3e,
  abstract     = {The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design.},
  author       = {Zanchetti, Alberto and Liu, Lisheng and Mancia, Giuseppe and Parati, Gianfranco and Grassi, Guido and Stramba-Badiale, Marco and Silani, Vincenzo and Bilo, Grzegorz and Corrao, Giovanni and Zambon, Antonella and Scotti, Lorenza and Zhang, Xinhua and Wang, HayYan and Zhang, Yuqing and Zhang, Xuezhong and Guan, Ting Rui and Berge, Eivind and Redon, Josep and Narkiewicz, Krzysztof and Dominiczak, Anna and Nilsson, Peter and Viigimaa, Margus and Laurent, Stéphane and Agabiti-Rosei, Enrico and Wu, Zhaosu and Zhu, Dingliang and Rodicio, José Luis and Ruilope, Luis Miguel and Martell-Claros, Nieves and Pinto, Fernando and Schmieder, Roland E and Burnier, Michel and Banach, Maciej and Cifkova, Renata and Farsang, Csaba and Konradi, Alexandra and Lazareva, Irina and Sirenko, Yuriy and Dorobantu, Maria and Postadzhiyan, Arman and Accetto, Rok and Jelakovic, Bojan and Lovic, Dragan and Manolis, Athanasios J and Stylianou, Philippos and Erdine, Serap and Dicker, Dror and Wei, Gangzhi and Xu, Chengbin and Xie, Hengge and Coca, Antonio and O'Brien, John and Ford, Gary},
  issn         = {1473-5598},
  language     = {eng},
  number       = {9},
  pages        = {1888--1897},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial.},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000000254},
  volume       = {32},
  year         = {2014},
}