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An electrocardiographic sign of ischemic preconditioning

Meijs, Loek P. B.; Galeotti, Loriano; Pueyo, Esther P.; Romero, Daniel; Jennings, Robert B.; Ringborn, Michael LU ; Warren, Stafford G.; Wagner, Galen S. and Strauss, David G. (2014) In American Journal of Physiology: Heart and Circulatory Physiology 307(1). p.80-87
Abstract
Ischemic preconditioning is a form of intrinsic cardioprotection where an episode of sublethal ischemia protects against subsequent episodes of ischemia. Identifying a clinical biomarker of preconditioning could have important clinical implications, and prior work has focused on the electrocardiographic ST segment. However, the electrophysiology biomarker of preconditioning is increased action potential duration (APD) shortening with subsequent ischemic episodes, and APD shortening should primarily alter the T wave, not the ST segment. We translated findings from simulations to canine to patient models of preconditioning to test the hypothesis that the combination of increased [delta (Delta)] T wave amplitude with decreased ST segment... (More)
Ischemic preconditioning is a form of intrinsic cardioprotection where an episode of sublethal ischemia protects against subsequent episodes of ischemia. Identifying a clinical biomarker of preconditioning could have important clinical implications, and prior work has focused on the electrocardiographic ST segment. However, the electrophysiology biomarker of preconditioning is increased action potential duration (APD) shortening with subsequent ischemic episodes, and APD shortening should primarily alter the T wave, not the ST segment. We translated findings from simulations to canine to patient models of preconditioning to test the hypothesis that the combination of increased [delta (Delta)] T wave amplitude with decreased ST segment elevation characterizes preconditioning. In simulations, decreased APD caused increased T wave amplitude with minimal ST segment elevation. In contrast, decreased action potential amplitude increased ST segment elevation significantly. In a canine model of preconditioning (9 mongrel dogs undergoing 4 ischemia-reperfusion episodes), ST segment amplitude increased more than T wave amplitude during the first ischemic episode [Delta T/Delta ST slope = 0.81, 95% confidence interval (CI) 0.46 -1.15]; however, during subsequent ischemic episodes the T wave increased significantly more than the ST segment (Delta T/Delta ST slope = 2.43, CI 2.07-2.80) (P = 0.001 for interaction of occlusions 2 vs. 1). A similar result was observed in patients (9 patients undergoing 2 consecutive prolonged occlusions during elective percutaneous coronary intervention), with an increase in slope of Delta T/Delta ST of 0.13 (CI = 0.15 to 0.42) in the first occlusion to 1.02 (CI 0.31-1.73) in the second occlusion (P = 0.02). This integrated analysis of the T wave and ST segment goes beyond the standard approach to only analyze ST elevation, and detects cellular electrophysiology changes of preconditioning. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute myocardial infarction, electrocardiology, electrophysiology, quantitative modeling
in
American Journal of Physiology: Heart and Circulatory Physiology
volume
307
issue
1
pages
80 - 87
publisher
American Physiological Society
external identifiers
  • wos:000338917200009
  • scopus:84903642847
ISSN
1522-1539
DOI
10.1152/ajpheart.00419.2013
language
English
LU publication?
yes
id
39590ae5-0967-4f7f-bf50-f5052a88bedb (old id 4595732)
date added to LUP
2014-09-05 11:13:54
date last changed
2017-01-15 03:19:53
@article{39590ae5-0967-4f7f-bf50-f5052a88bedb,
  abstract     = {Ischemic preconditioning is a form of intrinsic cardioprotection where an episode of sublethal ischemia protects against subsequent episodes of ischemia. Identifying a clinical biomarker of preconditioning could have important clinical implications, and prior work has focused on the electrocardiographic ST segment. However, the electrophysiology biomarker of preconditioning is increased action potential duration (APD) shortening with subsequent ischemic episodes, and APD shortening should primarily alter the T wave, not the ST segment. We translated findings from simulations to canine to patient models of preconditioning to test the hypothesis that the combination of increased [delta (Delta)] T wave amplitude with decreased ST segment elevation characterizes preconditioning. In simulations, decreased APD caused increased T wave amplitude with minimal ST segment elevation. In contrast, decreased action potential amplitude increased ST segment elevation significantly. In a canine model of preconditioning (9 mongrel dogs undergoing 4 ischemia-reperfusion episodes), ST segment amplitude increased more than T wave amplitude during the first ischemic episode [Delta T/Delta ST slope = 0.81, 95% confidence interval (CI) 0.46 -1.15]; however, during subsequent ischemic episodes the T wave increased significantly more than the ST segment (Delta T/Delta ST slope = 2.43, CI 2.07-2.80) (P = 0.001 for interaction of occlusions 2 vs. 1). A similar result was observed in patients (9 patients undergoing 2 consecutive prolonged occlusions during elective percutaneous coronary intervention), with an increase in slope of Delta T/Delta ST of 0.13 (CI = 0.15 to 0.42) in the first occlusion to 1.02 (CI 0.31-1.73) in the second occlusion (P = 0.02). This integrated analysis of the T wave and ST segment goes beyond the standard approach to only analyze ST elevation, and detects cellular electrophysiology changes of preconditioning.},
  author       = {Meijs, Loek P. B. and Galeotti, Loriano and Pueyo, Esther P. and Romero, Daniel and Jennings, Robert B. and Ringborn, Michael and Warren, Stafford G. and Wagner, Galen S. and Strauss, David G.},
  issn         = {1522-1539},
  keyword      = {acute myocardial infarction,electrocardiology,electrophysiology,quantitative modeling},
  language     = {eng},
  number       = {1},
  pages        = {80--87},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Heart and Circulatory Physiology},
  title        = {An electrocardiographic sign of ischemic preconditioning},
  url          = {http://dx.doi.org/10.1152/ajpheart.00419.2013},
  volume       = {307},
  year         = {2014},
}