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Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats

Duarte, João M N LU orcid ; Nogueira, Célia ; Mackie, Ken ; Oliveira, Catarina R ; Cunha, Rodrigo A and Köfalvi, Attila (2007) In Experimental Neurology 204(1). p.479-484
Abstract

In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB(1)R protein and of specific CB(1)R... (More)

In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB(1)R protein and of specific CB(1)R binding sites are significantly increased both in the nerve terminals and in total membranes (changes between 13% and 38%), whereas CB(1)R mRNA expression is decreased by 25%, suggesting that CB(1)Rs might play a role in diabetic encephalopathy.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Binding Sites, Diabetes Mellitus, Experimental/metabolism, Hippocampus/metabolism, Male, Membranes/metabolism, Nerve Endings/metabolism, RNA, Messenger/metabolism, Rats, Rats, Wistar, Receptor, Cannabinoid, CB1/genetics
in
Experimental Neurology
volume
204
issue
1
pages
6 pages
publisher
Elsevier
external identifiers
  • pmid:17222407
  • scopus:33847311708
ISSN
0014-4886
DOI
10.1016/j.expneurol.2006.11.013
language
English
LU publication?
no
id
45b02dad-af2e-4df2-9270-f7cc2c6492d7
date added to LUP
2019-02-22 09:18:04
date last changed
2024-01-30 10:42:14
@article{45b02dad-af2e-4df2-9270-f7cc2c6492d7,
  abstract     = {{<p>In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB(1)R protein and of specific CB(1)R binding sites are significantly increased both in the nerve terminals and in total membranes (changes between 13% and 38%), whereas CB(1)R mRNA expression is decreased by 25%, suggesting that CB(1)Rs might play a role in diabetic encephalopathy.</p>}},
  author       = {{Duarte, João M N and Nogueira, Célia and Mackie, Ken and Oliveira, Catarina R and Cunha, Rodrigo A and Köfalvi, Attila}},
  issn         = {{0014-4886}},
  keywords     = {{Animals; Binding Sites; Diabetes Mellitus, Experimental/metabolism; Hippocampus/metabolism; Male; Membranes/metabolism; Nerve Endings/metabolism; RNA, Messenger/metabolism; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1/genetics}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{479--484}},
  publisher    = {{Elsevier}},
  series       = {{Experimental Neurology}},
  title        = {{Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats}},
  url          = {{http://dx.doi.org/10.1016/j.expneurol.2006.11.013}},
  doi          = {{10.1016/j.expneurol.2006.11.013}},
  volume       = {{204}},
  year         = {{2007}},
}