Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
(2007) In Experimental Neurology 204(1). p.479-484- Abstract
In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB(1)R protein and of specific CB(1)R... (More)
In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB(1)R protein and of specific CB(1)R binding sites are significantly increased both in the nerve terminals and in total membranes (changes between 13% and 38%), whereas CB(1)R mRNA expression is decreased by 25%, suggesting that CB(1)Rs might play a role in diabetic encephalopathy.
(Less)
- author
- Duarte, João M N
LU
; Nogueira, Célia ; Mackie, Ken ; Oliveira, Catarina R ; Cunha, Rodrigo A and Köfalvi, Attila
- publishing date
- 2007-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Binding Sites, Diabetes Mellitus, Experimental/metabolism, Hippocampus/metabolism, Male, Membranes/metabolism, Nerve Endings/metabolism, RNA, Messenger/metabolism, Rats, Rats, Wistar, Receptor, Cannabinoid, CB1/genetics
- in
- Experimental Neurology
- volume
- 204
- issue
- 1
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:17222407
- scopus:33847311708
- ISSN
- 0014-4886
- DOI
- 10.1016/j.expneurol.2006.11.013
- language
- English
- LU publication?
- no
- id
- 45b02dad-af2e-4df2-9270-f7cc2c6492d7
- date added to LUP
- 2019-02-22 09:18:04
- date last changed
- 2024-01-30 10:42:14
@article{45b02dad-af2e-4df2-9270-f7cc2c6492d7, abstract = {{<p>In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB(1)R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB(1)R protein and of specific CB(1)R binding sites are significantly increased both in the nerve terminals and in total membranes (changes between 13% and 38%), whereas CB(1)R mRNA expression is decreased by 25%, suggesting that CB(1)Rs might play a role in diabetic encephalopathy.</p>}}, author = {{Duarte, João M N and Nogueira, Célia and Mackie, Ken and Oliveira, Catarina R and Cunha, Rodrigo A and Köfalvi, Attila}}, issn = {{0014-4886}}, keywords = {{Animals; Binding Sites; Diabetes Mellitus, Experimental/metabolism; Hippocampus/metabolism; Male; Membranes/metabolism; Nerve Endings/metabolism; RNA, Messenger/metabolism; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1/genetics}}, language = {{eng}}, number = {{1}}, pages = {{479--484}}, publisher = {{Elsevier}}, series = {{Experimental Neurology}}, title = {{Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats}}, url = {{http://dx.doi.org/10.1016/j.expneurol.2006.11.013}}, doi = {{10.1016/j.expneurol.2006.11.013}}, volume = {{204}}, year = {{2007}}, }