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Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes

Schrader, Silja LU ; Perfilyev, Alexander LU orcid ; Martinell, Mats ; García-Calzón, Sonia LU and Ling, Charlotte LU orcid (2021) In Epigenomics 13(12). p.919-925
Abstract

Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of... (More)

Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular disease, causal mediation analyses, DNA methylation, epigenetics, HDL, LDL, pharmacoepigenetics, statins, therapy, Type 2 diabetes, ANDIS, diabetes
in
Epigenomics
volume
13
issue
12
pages
7 pages
publisher
Future Medicine Ltd.
external identifiers
  • scopus:85106462654
  • pmid:33947200
ISSN
1750-1911
DOI
10.2217/epi-2020-0442
language
English
LU publication?
yes
id
45f6106c-2a63-4536-9eef-56a4977ce865
date added to LUP
2021-06-11 12:25:52
date last changed
2024-06-16 15:00:07
@article{45f6106c-2a63-4536-9eef-56a4977ce865,
  abstract     = {{<p>Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials &amp; methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate &lt;5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.</p>}},
  author       = {{Schrader, Silja and Perfilyev, Alexander and Martinell, Mats and García-Calzón, Sonia and Ling, Charlotte}},
  issn         = {{1750-1911}},
  keywords     = {{cardiovascular disease; causal mediation analyses; DNA methylation; epigenetics; HDL; LDL; pharmacoepigenetics; statins; therapy; Type 2 diabetes; ANDIS; diabetes}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{12}},
  pages        = {{919--925}},
  publisher    = {{Future Medicine Ltd.}},
  series       = {{Epigenomics}},
  title        = {{Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes}},
  url          = {{http://dx.doi.org/10.2217/epi-2020-0442}},
  doi          = {{10.2217/epi-2020-0442}},
  volume       = {{13}},
  year         = {{2021}},
}