Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes
(2021) In Epigenomics 13(12). p.919-925- Abstract
Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of... (More)
Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.
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- author
- Schrader, Silja LU ; Perfilyev, Alexander LU ; Martinell, Mats ; García-Calzón, Sonia LU and Ling, Charlotte LU
- organization
- publishing date
- 2021-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiovascular disease, causal mediation analyses, DNA methylation, epigenetics, HDL, LDL, pharmacoepigenetics, statins, therapy, Type 2 diabetes, ANDIS, diabetes
- in
- Epigenomics
- volume
- 13
- issue
- 12
- pages
- 7 pages
- publisher
- Future Medicine Ltd.
- external identifiers
-
- pmid:33947200
- scopus:85106462654
- ISSN
- 1750-1911
- DOI
- 10.2217/epi-2020-0442
- language
- English
- LU publication?
- yes
- id
- 45f6106c-2a63-4536-9eef-56a4977ce865
- date added to LUP
- 2021-06-11 12:25:52
- date last changed
- 2024-09-07 20:29:08
@article{45f6106c-2a63-4536-9eef-56a4977ce865, abstract = {{<p>Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.</p>}}, author = {{Schrader, Silja and Perfilyev, Alexander and Martinell, Mats and García-Calzón, Sonia and Ling, Charlotte}}, issn = {{1750-1911}}, keywords = {{cardiovascular disease; causal mediation analyses; DNA methylation; epigenetics; HDL; LDL; pharmacoepigenetics; statins; therapy; Type 2 diabetes; ANDIS; diabetes}}, language = {{eng}}, month = {{06}}, number = {{12}}, pages = {{919--925}}, publisher = {{Future Medicine Ltd.}}, series = {{Epigenomics}}, title = {{Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes}}, url = {{http://dx.doi.org/10.2217/epi-2020-0442}}, doi = {{10.2217/epi-2020-0442}}, volume = {{13}}, year = {{2021}}, }