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Risk factors for Clostridium difficile infection in the community: a case-control study in patients in general practice, Denmark, 2009-2011

Soes, L. M. ; Holt, H. M. ; Böttiger, Blenda LU ; Nielsen, H. V. ; Andreasen, V. ; Kemp, M. ; Olsen, K. E. P. ; Ethelberg, S. and Molbak, K. (2014) In Epidemiology and Infection 142(7). p.1437-1448
Abstract
To identify risk factors for Clostridium difficile infection (CDI) in Danish patients consulting general practice with gastrointestinal symptoms, a prospective matched case-control study was performed; cases (N=259) had positive cultures for toxigenic C. difficile and controls (N=455) negative cultures. Data were analysed by conditional logistic regression. In patients aged 2 years (138 cases), hospitalization [odds ratio (OR) 84, 95% confidence interval (CI) 31-23], consumption of beef (OR 55, 95% CI 20-15), phenoxymethylpenicillin (OR 15, 95% CI 27-82), dicloxacillin (OR 27, 95% CI 36-211), and extended spectrum penicillins (OR 92, 95% CI 19-45) were associated with CDI. In patients aged <2 years none of these were associated with... (More)
To identify risk factors for Clostridium difficile infection (CDI) in Danish patients consulting general practice with gastrointestinal symptoms, a prospective matched case-control study was performed; cases (N=259) had positive cultures for toxigenic C. difficile and controls (N=455) negative cultures. Data were analysed by conditional logistic regression. In patients aged 2 years (138 cases), hospitalization [odds ratio (OR) 84, 95% confidence interval (CI) 31-23], consumption of beef (OR 55, 95% CI 20-15), phenoxymethylpenicillin (OR 15, 95% CI 27-82), dicloxacillin (OR 27, 95% CI 36-211), and extended spectrum penicillins (OR 92, 95% CI 19-45) were associated with CDI. In patients aged <2 years none of these were associated with CDI, but in a subgroup analysis contact with animals was associated with CDI (OR 81, 95% CI 10-64). This study emphasizes narrow-spectrum penicillins, and suggests beef consumption, as risk factors for CDI in adults, and indicates a different epidemiology of CDI in infants. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotics, case-control study, children, community-associated, Clostridium difficile infection, zoonoses
in
Epidemiology and Infection
volume
142
issue
7
pages
1437 - 1448
publisher
Cambridge University Press
external identifiers
  • wos:000337306100012
  • scopus:84901634395
  • pmid:24073613
ISSN
0950-2688
DOI
10.1017/S0950268813002380
language
English
LU publication?
yes
id
7cb0538f-90a1-451f-9669-5cda3a0447f5 (old id 4609394)
date added to LUP
2016-04-01 11:05:16
date last changed
2025-04-04 14:47:50
@article{7cb0538f-90a1-451f-9669-5cda3a0447f5,
  abstract     = {{To identify risk factors for Clostridium difficile infection (CDI) in Danish patients consulting general practice with gastrointestinal symptoms, a prospective matched case-control study was performed; cases (N=259) had positive cultures for toxigenic C. difficile and controls (N=455) negative cultures. Data were analysed by conditional logistic regression. In patients aged 2 years (138 cases), hospitalization [odds ratio (OR) 84, 95% confidence interval (CI) 31-23], consumption of beef (OR 55, 95% CI 20-15), phenoxymethylpenicillin (OR 15, 95% CI 27-82), dicloxacillin (OR 27, 95% CI 36-211), and extended spectrum penicillins (OR 92, 95% CI 19-45) were associated with CDI. In patients aged &lt;2 years none of these were associated with CDI, but in a subgroup analysis contact with animals was associated with CDI (OR 81, 95% CI 10-64). This study emphasizes narrow-spectrum penicillins, and suggests beef consumption, as risk factors for CDI in adults, and indicates a different epidemiology of CDI in infants.}},
  author       = {{Soes, L. M. and Holt, H. M. and Böttiger, Blenda and Nielsen, H. V. and Andreasen, V. and Kemp, M. and Olsen, K. E. P. and Ethelberg, S. and Molbak, K.}},
  issn         = {{0950-2688}},
  keywords     = {{Antibiotics; case-control study; children; community-associated; Clostridium difficile infection; zoonoses}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1437--1448}},
  publisher    = {{Cambridge University Press}},
  series       = {{Epidemiology and Infection}},
  title        = {{Risk factors for Clostridium difficile infection in the community: a case-control study in patients in general practice, Denmark, 2009-2011}},
  url          = {{http://dx.doi.org/10.1017/S0950268813002380}},
  doi          = {{10.1017/S0950268813002380}},
  volume       = {{142}},
  year         = {{2014}},
}