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Capturing individual-level parameters of influenza A virus dynamics in wild ducks using multistate models

Avril, Alexis; Grosbois, Vladimir; Latorre-Margalef, Neus LU ; Gaidet, Nicolas; Tolf, Conny; Olsen, Björn and Waldenström, Jonas LU (2016) In Journal of Applied Ecology 53(4). p.1289-1297
Abstract

Disease prevalence in wildlife is governed by epidemiological parameters (infection and recovery rates) and response to infection, both of which vary within and among individual hosts. Studies quantifying these individual-scale parameters and documenting their source of variation in wild hosts are fundamental for predicting disease dynamics. Such studies do not exist for the influenza A virus (IAV), despite its strong impact on the global economy and public health. Using capture–recaptures of 3500 individual mallards Anas platyrhynchos during seven migration seasons at a stopover site in southern Sweden, we provide the first empirical description of the individual-based mechanisms of IAV dynamics in a wild reservoir host. For most... (More)

Disease prevalence in wildlife is governed by epidemiological parameters (infection and recovery rates) and response to infection, both of which vary within and among individual hosts. Studies quantifying these individual-scale parameters and documenting their source of variation in wild hosts are fundamental for predicting disease dynamics. Such studies do not exist for the influenza A virus (IAV), despite its strong impact on the global economy and public health. Using capture–recaptures of 3500 individual mallards Anas platyrhynchos during seven migration seasons at a stopover site in southern Sweden, we provide the first empirical description of the individual-based mechanisms of IAV dynamics in a wild reservoir host. For most years, prevalence and risk of IAV infection peaked at a single time during the autumn migration season, but the timing, shape and intensity of the infection curve showed strong annual heterogeneity. In contrast, the seasonal pattern of recovery rate only varied in intensity across years. Adults and juveniles displayed similar seasonal patterns of infection and recovery each year. However, compared to adults, juveniles experienced twice the risk of becoming infected, whereas recovery rates were similar across age categories. Finally, we did not find evidence that infection influenced the timing of emigration. Synthesis and applications. Our study provides robust empirical estimates of epidemiological parameters for predicting influenza A virus (IAV) dynamics. However, the strong annual variation in infection curves makes forecasting difficult. Prevalence data can provide reliable surveillance indicators as long as they catch the variation in infection risk. However, individual-based monitoring of infection is required to verify this assumption in areas where surveillance occurs. In this context, monitoring of captive sentinel birds kept in close contact with wild birds is useful. The fact that infection does not impact the timing of migration underpins the potential for mallards to spread viruses rapidly over large geographical scales. Hence, we strongly encourage IAV surveillance with a multistate capture–recapture approach along the entire migratory flyway of mallards.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
avian influenza, epidemiology, host–pathogen dynamics, individual-based monitoring, influenza A virus, multistate capture–recapture, outbreaks, SIR model, waterfowl, zoonosis
in
Journal of Applied Ecology
volume
53
issue
4
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84973607340
ISSN
0021-8901
DOI
10.1111/1365-2664.12699
language
English
LU publication?
no
id
460f6779-e362-4fb2-9235-54dff703534c
date added to LUP
2017-04-11 13:57:47
date last changed
2017-08-27 06:39:08
@article{460f6779-e362-4fb2-9235-54dff703534c,
  abstract     = {<p>Disease prevalence in wildlife is governed by epidemiological parameters (infection and recovery rates) and response to infection, both of which vary within and among individual hosts. Studies quantifying these individual-scale parameters and documenting their source of variation in wild hosts are fundamental for predicting disease dynamics. Such studies do not exist for the influenza A virus (IAV), despite its strong impact on the global economy and public health. Using capture–recaptures of 3500 individual mallards Anas platyrhynchos during seven migration seasons at a stopover site in southern Sweden, we provide the first empirical description of the individual-based mechanisms of IAV dynamics in a wild reservoir host. For most years, prevalence and risk of IAV infection peaked at a single time during the autumn migration season, but the timing, shape and intensity of the infection curve showed strong annual heterogeneity. In contrast, the seasonal pattern of recovery rate only varied in intensity across years. Adults and juveniles displayed similar seasonal patterns of infection and recovery each year. However, compared to adults, juveniles experienced twice the risk of becoming infected, whereas recovery rates were similar across age categories. Finally, we did not find evidence that infection influenced the timing of emigration. Synthesis and applications. Our study provides robust empirical estimates of epidemiological parameters for predicting influenza A virus (IAV) dynamics. However, the strong annual variation in infection curves makes forecasting difficult. Prevalence data can provide reliable surveillance indicators as long as they catch the variation in infection risk. However, individual-based monitoring of infection is required to verify this assumption in areas where surveillance occurs. In this context, monitoring of captive sentinel birds kept in close contact with wild birds is useful. The fact that infection does not impact the timing of migration underpins the potential for mallards to spread viruses rapidly over large geographical scales. Hence, we strongly encourage IAV surveillance with a multistate capture–recapture approach along the entire migratory flyway of mallards.</p>},
  author       = {Avril, Alexis and Grosbois, Vladimir and Latorre-Margalef, Neus and Gaidet, Nicolas and Tolf, Conny and Olsen, Björn and Waldenström, Jonas},
  issn         = {0021-8901},
  keyword      = {avian influenza,epidemiology,host–pathogen dynamics,individual-based monitoring,influenza A virus,multistate capture–recapture,outbreaks,SIR model,waterfowl,zoonosis},
  language     = {eng},
  month        = {08},
  number       = {4},
  pages        = {1289--1297},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Applied Ecology},
  title        = {Capturing individual-level parameters of influenza A virus dynamics in wild ducks using multistate models},
  url          = {http://dx.doi.org/10.1111/1365-2664.12699},
  volume       = {53},
  year         = {2016},
}