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Breakdown of Whole-brain Dynamics in Preterm-born Children

Padilla, Nelly ; Saenger, Victor M. ; Van Hartevelt, Tim J. ; Fernandes, Henrique M. ; Lennartsson, Finn LU ; Andersson, Jesper L.R. ; Kringelbach, Morten ; Deco, Gustavo and Åden, Ulrika (2020) In Cerebral Cortex 30(3). p.1159-1170
Abstract

The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at < 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a... (More)

The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at < 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a whole-brain Hopf model, to define the level of stability, desynchronization, or criticality of the brain. EPT-born children exhibited fewer intrinsic ignition events than controls; nodes were related to less sophisticated aspects of cognitive control, and there was a different hierarchy pattern in the propagation of information and suboptimal synchronicity and criticality. The largest differences were found in brain nodes belonging to the rich-club architecture. These results provide important insights into the neural substrates underlying brain reorganization and neurodevelopmental impairments related to prematurity.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain development, brain dynamics, functional connectivity, neurodevelopment, prematurity
in
Cerebral Cortex
volume
30
issue
3
pages
12 pages
publisher
Oxford University Press
external identifiers
  • pmid:31504269
  • scopus:85083042663
ISSN
1047-3211
DOI
10.1093/cercor/bhz156
language
English
LU publication?
yes
id
4611f7f2-72a4-42a8-af0f-434781420f7b
date added to LUP
2020-05-05 15:55:08
date last changed
2024-06-12 13:37:59
@article{4611f7f2-72a4-42a8-af0f-434781420f7b,
  abstract     = {{<p>The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at &lt; 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a whole-brain Hopf model, to define the level of stability, desynchronization, or criticality of the brain. EPT-born children exhibited fewer intrinsic ignition events than controls; nodes were related to less sophisticated aspects of cognitive control, and there was a different hierarchy pattern in the propagation of information and suboptimal synchronicity and criticality. The largest differences were found in brain nodes belonging to the rich-club architecture. These results provide important insights into the neural substrates underlying brain reorganization and neurodevelopmental impairments related to prematurity.</p>}},
  author       = {{Padilla, Nelly and Saenger, Victor M. and Van Hartevelt, Tim J. and Fernandes, Henrique M. and Lennartsson, Finn and Andersson, Jesper L.R. and Kringelbach, Morten and Deco, Gustavo and Åden, Ulrika}},
  issn         = {{1047-3211}},
  keywords     = {{brain development; brain dynamics; functional connectivity; neurodevelopment; prematurity}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1159--1170}},
  publisher    = {{Oxford University Press}},
  series       = {{Cerebral Cortex}},
  title        = {{Breakdown of Whole-brain Dynamics in Preterm-born Children}},
  url          = {{http://dx.doi.org/10.1093/cercor/bhz156}},
  doi          = {{10.1093/cercor/bhz156}},
  volume       = {{30}},
  year         = {{2020}},
}