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Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.

Tada, Hayato ; Won, Hong-Hee ; Melander, Olle LU ; Yang, Jian ; Peloso, Gina M and Kathiresan, Sekar (2014) In Circulation: Cardiovascular Genetics 7(5). p.583-587
Abstract
-Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD.
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Circulation: Cardiovascular Genetics
volume
7
issue
5
pages
583 - 587
publisher
American Heart Association
external identifiers
  • pmid:25170055
  • wos:000344368200004
  • scopus:84925860386
  • pmid:25170055
ISSN
1942-325X
DOI
10.1161/CIRCGENETICS.113.000420
language
English
LU publication?
yes
id
39bcce0e-2616-4d74-b1f3-c7e157187d43 (old id 4612723)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25170055?dopt=Abstract
date added to LUP
2016-04-01 10:21:07
date last changed
2022-03-12 04:55:35
@article{39bcce0e-2616-4d74-b1f3-c7e157187d43,
  abstract     = {{-Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD.}},
  author       = {{Tada, Hayato and Won, Hong-Hee and Melander, Olle and Yang, Jian and Peloso, Gina M and Kathiresan, Sekar}},
  issn         = {{1942-325X}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{583--587}},
  publisher    = {{American Heart Association}},
  series       = {{Circulation: Cardiovascular Genetics}},
  title        = {{Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.}},
  url          = {{http://dx.doi.org/10.1161/CIRCGENETICS.113.000420}},
  doi          = {{10.1161/CIRCGENETICS.113.000420}},
  volume       = {{7}},
  year         = {{2014}},
}