Genetics of diabetes complications.
(2014) In Mammalian Genome 25(9-10). p.384-400- Abstract
- Chronic hyperglycemia and duration of diabetes are the major risk factors associated with development of micro- and macrovascular complications of diabetes. Although it is believed that hyperglycemia induces damage to the particular cell subtypes, e.g., mesangial cells in the renal glomerulus, capillary endothelial cells in the retina, and neurons and Schwann cells in peripheral nerves, the exact mechanisms underlying these damaging defects are not yet well understood. Clustering of micro- and macrovascular complications in families of patients with diabetes suggests a strong genetic susceptibility. However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and... (More)
- Chronic hyperglycemia and duration of diabetes are the major risk factors associated with development of micro- and macrovascular complications of diabetes. Although it is believed that hyperglycemia induces damage to the particular cell subtypes, e.g., mesangial cells in the renal glomerulus, capillary endothelial cells in the retina, and neurons and Schwann cells in peripheral nerves, the exact mechanisms underlying these damaging defects are not yet well understood. Clustering of micro- and macrovascular complications in families of patients with diabetes suggests a strong genetic susceptibility. However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes. It is, therefore, obvious that the accumulation of more data from larger studies and better phenotypically characterized cohorts is needed to facilitate genetic discoveries and unravel novel insights into the pathogenesis of diabetic complications. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4612732
- author
- Alkayyali, Sami LU and Lyssenko, Valeriya LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Mammalian Genome
- volume
- 25
- issue
- 9-10
- pages
- 384 - 400
- publisher
- Springer
- external identifiers
-
- pmid:25169573
- wos:000342173700003
- pmid:25169573
- scopus:84929509269
- ISSN
- 1432-1777
- DOI
- 10.1007/s00335-014-9543-x
- language
- English
- LU publication?
- yes
- id
- b559f7a6-6910-48bc-948c-292de4331a15 (old id 4612732)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25169573?dopt=Abstract
- date added to LUP
- 2016-04-01 10:18:42
- date last changed
- 2024-01-06 13:29:29
@article{b559f7a6-6910-48bc-948c-292de4331a15,
abstract = {{Chronic hyperglycemia and duration of diabetes are the major risk factors associated with development of micro- and macrovascular complications of diabetes. Although it is believed that hyperglycemia induces damage to the particular cell subtypes, e.g., mesangial cells in the renal glomerulus, capillary endothelial cells in the retina, and neurons and Schwann cells in peripheral nerves, the exact mechanisms underlying these damaging defects are not yet well understood. Clustering of micro- and macrovascular complications in families of patients with diabetes suggests a strong genetic susceptibility. However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes. It is, therefore, obvious that the accumulation of more data from larger studies and better phenotypically characterized cohorts is needed to facilitate genetic discoveries and unravel novel insights into the pathogenesis of diabetic complications.}},
author = {{Alkayyali, Sami and Lyssenko, Valeriya}},
issn = {{1432-1777}},
language = {{eng}},
number = {{9-10}},
pages = {{384--400}},
publisher = {{Springer}},
series = {{Mammalian Genome}},
title = {{Genetics of diabetes complications.}},
url = {{http://dx.doi.org/10.1007/s00335-014-9543-x}},
doi = {{10.1007/s00335-014-9543-x}},
volume = {{25}},
year = {{2014}},
}