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Genetics of diabetes complications.

Alkayyali, Sami LU and Lyssenko, Valeriya LU (2014) In Mammalian Genome 25(9-10). p.384-400
Abstract
Chronic hyperglycemia and duration of diabetes are the major risk factors associated with development of micro- and macrovascular complications of diabetes. Although it is believed that hyperglycemia induces damage to the particular cell subtypes, e.g., mesangial cells in the renal glomerulus, capillary endothelial cells in the retina, and neurons and Schwann cells in peripheral nerves, the exact mechanisms underlying these damaging defects are not yet well understood. Clustering of micro- and macrovascular complications in families of patients with diabetes suggests a strong genetic susceptibility. However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and... (More)
Chronic hyperglycemia and duration of diabetes are the major risk factors associated with development of micro- and macrovascular complications of diabetes. Although it is believed that hyperglycemia induces damage to the particular cell subtypes, e.g., mesangial cells in the renal glomerulus, capillary endothelial cells in the retina, and neurons and Schwann cells in peripheral nerves, the exact mechanisms underlying these damaging defects are not yet well understood. Clustering of micro- and macrovascular complications in families of patients with diabetes suggests a strong genetic susceptibility. However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes. It is, therefore, obvious that the accumulation of more data from larger studies and better phenotypically characterized cohorts is needed to facilitate genetic discoveries and unravel novel insights into the pathogenesis of diabetic complications. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mammalian Genome
volume
25
issue
9-10
pages
384 - 400
publisher
Springer
external identifiers
  • pmid:25169573
  • wos:000342173700003
  • scopus:84929509269
ISSN
1432-1777
DOI
10.1007/s00335-014-9543-x
language
English
LU publication?
yes
id
b559f7a6-6910-48bc-948c-292de4331a15 (old id 4612732)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25169573?dopt=Abstract
date added to LUP
2014-09-09 19:31:11
date last changed
2017-11-12 03:06:21
@article{b559f7a6-6910-48bc-948c-292de4331a15,
  abstract     = {Chronic hyperglycemia and duration of diabetes are the major risk factors associated with development of micro- and macrovascular complications of diabetes. Although it is believed that hyperglycemia induces damage to the particular cell subtypes, e.g., mesangial cells in the renal glomerulus, capillary endothelial cells in the retina, and neurons and Schwann cells in peripheral nerves, the exact mechanisms underlying these damaging defects are not yet well understood. Clustering of micro- and macrovascular complications in families of patients with diabetes suggests a strong genetic susceptibility. However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes. It is, therefore, obvious that the accumulation of more data from larger studies and better phenotypically characterized cohorts is needed to facilitate genetic discoveries and unravel novel insights into the pathogenesis of diabetic complications.},
  author       = {Alkayyali, Sami and Lyssenko, Valeriya},
  issn         = {1432-1777},
  language     = {eng},
  number       = {9-10},
  pages        = {384--400},
  publisher    = {Springer},
  series       = {Mammalian Genome},
  title        = {Genetics of diabetes complications.},
  url          = {http://dx.doi.org/10.1007/s00335-014-9543-x},
  volume       = {25},
  year         = {2014},
}