Epidermal Growth Factor-like Domain 7 Predicts Response to First-Line Chemotherapy and Bevacizumab in Patients with Metastatic Colorectal Cancer.
(2014) In Molecular Cancer Therapeutics 13(9). p.2238-2245- Abstract
- The number of approved antiangiogenic drugs is constantly growing and emphasizes the need for predictive biomarkers. The aim of this study was to analyze the predictive value of epidermal growth factor-like domain 7 (EGFL7) and microRNA-126 (miR126) to first-line chemotherapy combined with bevacizumab, in patients with metastatic colorectal cancer (mCRC). A total of 158 patients from two different, but comparable, cohorts were included. Analyses were performed on tumor tissue from the primary tumor either based on a whole-tumor resection or an endoscopic biopsy. EGFL7 was analyzed by immunohistochemistry (IHC) and miR126 by in situ hybridization (ISH). Both biomarkers were quantified by image-guided analyses. Endpoints were response rate... (More)
- The number of approved antiangiogenic drugs is constantly growing and emphasizes the need for predictive biomarkers. The aim of this study was to analyze the predictive value of epidermal growth factor-like domain 7 (EGFL7) and microRNA-126 (miR126) to first-line chemotherapy combined with bevacizumab, in patients with metastatic colorectal cancer (mCRC). A total of 158 patients from two different, but comparable, cohorts were included. Analyses were performed on tumor tissue from the primary tumor either based on a whole-tumor resection or an endoscopic biopsy. EGFL7 was analyzed by immunohistochemistry (IHC) and miR126 by in situ hybridization (ISH). Both biomarkers were quantified by image-guided analyses. Endpoints were response rate (RR) and progression-free survival (PFS). The EGFL7 vessel area (VA) in tumor resections was closely related to treatment response with a median EGFL7 VA in responding patients of 4 [95% confidence interval (CI), 4-6] compared with 8.5 (95% CI, 7-11) in nonresponders, P = 0.0008. This difference translated into a borderline significant difference in PFS (P = 0.06). Furthermore, a significant relationship between high EGFL7 VA and KRAS mutation was detected (P = 0.049). The results showed no significant relationship between the miR126 VA and the clinical endpoints. Our study suggests a predictive value of EGFL7 in regard to first-line chemotherapy and bevacizumab in patients with mCRC and supports the mechanism of a dual blocking of the vascular endothelial growth factor-A and EGFL7 axis in this setting. Mol Cancer Ther; 13(9); 1-8. ©2014 AACR. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4614265
- author
- Hansen, Torben Frøstrup ; Nielsen, Boye Schnack ; Sørensen, Flemming Brandt ; Johnsson, Anders LU and Jakobsen, Anders
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Cancer Therapeutics
- volume
- 13
- issue
- 9
- pages
- 2238 - 2245
- publisher
- American Association for Cancer Research
- external identifiers
-
- pmid:25140000
- wos:000341660800010
- scopus:84907202600
- pmid:25140000
- ISSN
- 1538-8514
- DOI
- 10.1158/1535-7163.MCT-14-0131
- language
- English
- LU publication?
- yes
- id
- 97e04d15-9b9a-4240-a16e-2d9dd616efa1 (old id 4614265)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25140000?dopt=Abstract
- date added to LUP
- 2016-04-01 11:14:41
- date last changed
- 2022-04-28 08:23:27
@article{97e04d15-9b9a-4240-a16e-2d9dd616efa1, abstract = {{The number of approved antiangiogenic drugs is constantly growing and emphasizes the need for predictive biomarkers. The aim of this study was to analyze the predictive value of epidermal growth factor-like domain 7 (EGFL7) and microRNA-126 (miR126) to first-line chemotherapy combined with bevacizumab, in patients with metastatic colorectal cancer (mCRC). A total of 158 patients from two different, but comparable, cohorts were included. Analyses were performed on tumor tissue from the primary tumor either based on a whole-tumor resection or an endoscopic biopsy. EGFL7 was analyzed by immunohistochemistry (IHC) and miR126 by in situ hybridization (ISH). Both biomarkers were quantified by image-guided analyses. Endpoints were response rate (RR) and progression-free survival (PFS). The EGFL7 vessel area (VA) in tumor resections was closely related to treatment response with a median EGFL7 VA in responding patients of 4 [95% confidence interval (CI), 4-6] compared with 8.5 (95% CI, 7-11) in nonresponders, P = 0.0008. This difference translated into a borderline significant difference in PFS (P = 0.06). Furthermore, a significant relationship between high EGFL7 VA and KRAS mutation was detected (P = 0.049). The results showed no significant relationship between the miR126 VA and the clinical endpoints. Our study suggests a predictive value of EGFL7 in regard to first-line chemotherapy and bevacizumab in patients with mCRC and supports the mechanism of a dual blocking of the vascular endothelial growth factor-A and EGFL7 axis in this setting. Mol Cancer Ther; 13(9); 1-8. ©2014 AACR.}}, author = {{Hansen, Torben Frøstrup and Nielsen, Boye Schnack and Sørensen, Flemming Brandt and Johnsson, Anders and Jakobsen, Anders}}, issn = {{1538-8514}}, language = {{eng}}, number = {{9}}, pages = {{2238--2245}}, publisher = {{American Association for Cancer Research}}, series = {{Molecular Cancer Therapeutics}}, title = {{Epidermal Growth Factor-like Domain 7 Predicts Response to First-Line Chemotherapy and Bevacizumab in Patients with Metastatic Colorectal Cancer.}}, url = {{http://dx.doi.org/10.1158/1535-7163.MCT-14-0131}}, doi = {{10.1158/1535-7163.MCT-14-0131}}, volume = {{13}}, year = {{2014}}, }