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Idiopathic normal pressure hydrocephalus: cerebral perfusion measured with pCASL before and repeatedly after CSF removal.

Virhammar, Johan; Laurell, Katarina; Ahlgren, André LU ; Cesarini, Kristina Giuliana and Larsson, Elna-Marie LU (2014) In Journal of Cerebral Blood Flow and Metabolism 34(11). p.1771-1778
Abstract
Pseudo-continuous arterial spin labeling (pCASL) measurements were performed in 20 patients with idiopathic normal pressure hydrocephalus (iNPH) to investigate whether cerebral blood flow (CBF) increases during the first 24 hours after a cerebrospinal fluid tap test (CSF TT). Five pCASL magnetic resonance imaging (MRI) scans were performed. Two scans were performed before removal of 40 mL CSF, and the other three at 30 minutes, 4 hours, and 24 hours, respectively after the CSF TT. Thirteen different regions of interest (ROIs) were manually drawn on coregistered MR images. In patients with increased CBF in lateral and frontal white matter after the CSF TT, gait function improved more than it did in patients with decreased CBF in these... (More)
Pseudo-continuous arterial spin labeling (pCASL) measurements were performed in 20 patients with idiopathic normal pressure hydrocephalus (iNPH) to investigate whether cerebral blood flow (CBF) increases during the first 24 hours after a cerebrospinal fluid tap test (CSF TT). Five pCASL magnetic resonance imaging (MRI) scans were performed. Two scans were performed before removal of 40 mL CSF, and the other three at 30 minutes, 4 hours, and 24 hours, respectively after the CSF TT. Thirteen different regions of interest (ROIs) were manually drawn on coregistered MR images. In patients with increased CBF in lateral and frontal white matter after the CSF TT, gait function improved more than it did in patients with decreased CBF in these regions. However, in the whole sample, there was no significant increase in CBF after CSF removal compared with baseline investigations. The repeatability of CBF measurements at baseline was high, with intraclass correlation coefficients of 0.60 to 0.90 for different ROIs, but the median regional variability was in the range of 5% to 17%. Our results indicate that CBF in white matter close to the lateral ventricles plays a role in the reversibility of symptoms after CSF removal in patients with iNPH.Journal of Cerebral Blood Flow & Metabolism advance online publication, 20 August 2014; doi:10.1038/jcbfm.2014.138. (Less)
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Contribution to journal
publication status
published
subject
in
Journal of Cerebral Blood Flow and Metabolism
volume
34
issue
11
pages
1771 - 1778
publisher
Nature Publishing Group
external identifiers
  • pmid:25138210
  • wos:000344428800005
  • scopus:84922215845
ISSN
1559-7016
DOI
10.1038/jcbfm.2014.138
language
English
LU publication?
yes
id
59bfafd9-6a82-4d19-baa9-770f06e12dff (old id 4614320)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25138210?dopt=Abstract
date added to LUP
2014-09-07 17:14:08
date last changed
2017-10-22 03:03:35
@article{59bfafd9-6a82-4d19-baa9-770f06e12dff,
  abstract     = {Pseudo-continuous arterial spin labeling (pCASL) measurements were performed in 20 patients with idiopathic normal pressure hydrocephalus (iNPH) to investigate whether cerebral blood flow (CBF) increases during the first 24 hours after a cerebrospinal fluid tap test (CSF TT). Five pCASL magnetic resonance imaging (MRI) scans were performed. Two scans were performed before removal of 40 mL CSF, and the other three at 30 minutes, 4 hours, and 24 hours, respectively after the CSF TT. Thirteen different regions of interest (ROIs) were manually drawn on coregistered MR images. In patients with increased CBF in lateral and frontal white matter after the CSF TT, gait function improved more than it did in patients with decreased CBF in these regions. However, in the whole sample, there was no significant increase in CBF after CSF removal compared with baseline investigations. The repeatability of CBF measurements at baseline was high, with intraclass correlation coefficients of 0.60 to 0.90 for different ROIs, but the median regional variability was in the range of 5% to 17%. Our results indicate that CBF in white matter close to the lateral ventricles plays a role in the reversibility of symptoms after CSF removal in patients with iNPH.Journal of Cerebral Blood Flow & Metabolism advance online publication, 20 August 2014; doi:10.1038/jcbfm.2014.138.},
  author       = {Virhammar, Johan and Laurell, Katarina and Ahlgren, André and Cesarini, Kristina Giuliana and Larsson, Elna-Marie},
  issn         = {1559-7016},
  language     = {eng},
  number       = {11},
  pages        = {1771--1778},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {Idiopathic normal pressure hydrocephalus: cerebral perfusion measured with pCASL before and repeatedly after CSF removal.},
  url          = {http://dx.doi.org/10.1038/jcbfm.2014.138},
  volume       = {34},
  year         = {2014},
}