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Male patients with terminal renal failure exhibit low serum levels of antimüllerian hormone.

Eckersten, Dag LU ; Giwercman, Aleksander LU and Christensson, Anders LU (2015) In Asian Journal of Andrology 17(1). p.149-153
Abstract
Male reproductive function is impaired during end-stage renal disease (ESRD). Disturbance of the hypothalamic-pituitary-gonadal axis, and therefore the regulation of sex hormones, is one of the major causes. Our focus was to include antimüllerian hormone (AMH) and inhibin B concentrations. Twenty male patients on hemodialysis, median age 40 (26-48) years, were analyzed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, sex hormone-binding globulin (SHBG), testosterone, estradiol, AMH and inhibin B levels. We used 144 proven fertile men, median age 32 (19-44) years as a control group and analyzed differences using multiple linear regression. Males with ESRD demonstrated higher mean values for prolactin, 742 versus... (More)
Male reproductive function is impaired during end-stage renal disease (ESRD). Disturbance of the hypothalamic-pituitary-gonadal axis, and therefore the regulation of sex hormones, is one of the major causes. Our focus was to include antimüllerian hormone (AMH) and inhibin B concentrations. Twenty male patients on hemodialysis, median age 40 (26-48) years, were analyzed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, sex hormone-binding globulin (SHBG), testosterone, estradiol, AMH and inhibin B levels. We used 144 proven fertile men, median age 32 (19-44) years as a control group and analyzed differences using multiple linear regression. Males with ESRD demonstrated higher mean values for prolactin, 742 versus normal 210 mIE l-1 (95% confidence interval (CI): 60.3, 729), LH, 8.87 versus normal 4.5 IE l-1 (95% CI: 2.75, 6.14), and estradiol 89.7 versus normal 79.0 pmol l-1 (95% CI: -1.31, -0.15). Mean value for AMH was lower, 19.5 versus normal 47.3 pmol l-1 (95% CI: -37.6, -11.6). There were no differences found for FSH, SHBG, inhibin B and testosterone. The most important difference was found for AMH, a marker of Sertoli cell function in the testes, which decreased by close to 60% when compared with controls. Combined with an increase in LH, these findings may indicate a dysfunction of Sertoli cells and an effect on Leydig cells contributing to a potential mechanism of reproductive dysfunction in men with ESRD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Asian Journal of Andrology
volume
17
issue
1
pages
149 - 153
publisher
Nature Publishing Group
external identifiers
  • pmid:25130586
  • wos:000352069100027
  • scopus:84920394232
ISSN
1008-682X
DOI
10.4103/1008-682X.135124
language
English
LU publication?
yes
id
2f9e5678-358b-423a-a416-a3ae9ad6ea5c (old id 4614470)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25130586?dopt=Abstract
date added to LUP
2014-09-07 16:22:25
date last changed
2017-07-30 03:08:31
@article{2f9e5678-358b-423a-a416-a3ae9ad6ea5c,
  abstract     = {Male reproductive function is impaired during end-stage renal disease (ESRD). Disturbance of the hypothalamic-pituitary-gonadal axis, and therefore the regulation of sex hormones, is one of the major causes. Our focus was to include antimüllerian hormone (AMH) and inhibin B concentrations. Twenty male patients on hemodialysis, median age 40 (26-48) years, were analyzed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, sex hormone-binding globulin (SHBG), testosterone, estradiol, AMH and inhibin B levels. We used 144 proven fertile men, median age 32 (19-44) years as a control group and analyzed differences using multiple linear regression. Males with ESRD demonstrated higher mean values for prolactin, 742 versus normal 210 mIE l-1 (95% confidence interval (CI): 60.3, 729), LH, 8.87 versus normal 4.5 IE l-1 (95% CI: 2.75, 6.14), and estradiol 89.7 versus normal 79.0 pmol l-1 (95% CI: -1.31, -0.15). Mean value for AMH was lower, 19.5 versus normal 47.3 pmol l-1 (95% CI: -37.6, -11.6). There were no differences found for FSH, SHBG, inhibin B and testosterone. The most important difference was found for AMH, a marker of Sertoli cell function in the testes, which decreased by close to 60% when compared with controls. Combined with an increase in LH, these findings may indicate a dysfunction of Sertoli cells and an effect on Leydig cells contributing to a potential mechanism of reproductive dysfunction in men with ESRD.},
  author       = {Eckersten, Dag and Giwercman, Aleksander and Christensson, Anders},
  issn         = {1008-682X},
  language     = {eng},
  number       = {1},
  pages        = {149--153},
  publisher    = {Nature Publishing Group},
  series       = {Asian Journal of Andrology},
  title        = {Male patients with terminal renal failure exhibit low serum levels of antimüllerian hormone.},
  url          = {http://dx.doi.org/10.4103/1008-682X.135124},
  volume       = {17},
  year         = {2015},
}