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A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality.

Bay-Richter, Cecilie LU ; Linderholm, Klas R; Lim, Chai K; Samuelsson, Martin; Träskman Bendz, Lil LU ; Guillemin, Gilles J; Erhardt, Sophie and Brundin, Lena LU (2015) In Brain Behavior and Immunity 43(Aug 12). p.110-117
Abstract
Patients with depression and suicidality suffer from low-grade neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase, an initial enzyme of the kynurenine pathway. This pathway produces neuroactive metabolites, including quinolinic- and kynurenic acid, binding to the glutamate N-methyl-d-aspartate-receptor, which is hypothesized to be part of the neural mechanisms underlying symptoms of depression. We therefore hypothesized that symptoms of depression and suicidality would fluctuate over time in patients prone to suicidal behavior, depending on the degree of inflammation and kynurenine metabolite levels in the cerebrospinal fluid (CSF).
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Brain Behavior and Immunity
volume
43
issue
Aug 12
pages
110 - 117
publisher
Elsevier
external identifiers
  • pmid:25124710
  • wos:000360592700015
  • scopus:84919402536
ISSN
1090-2139
DOI
10.1016/j.bbi.2014.07.012
language
English
LU publication?
yes
id
acf9212c-fba8-41be-9598-f4e9e2e37469 (old id 4614563)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25124710?dopt=Abstract
date added to LUP
2014-09-07 16:03:20
date last changed
2017-11-12 03:17:08
@article{acf9212c-fba8-41be-9598-f4e9e2e37469,
  abstract     = {Patients with depression and suicidality suffer from low-grade neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase, an initial enzyme of the kynurenine pathway. This pathway produces neuroactive metabolites, including quinolinic- and kynurenic acid, binding to the glutamate N-methyl-d-aspartate-receptor, which is hypothesized to be part of the neural mechanisms underlying symptoms of depression. We therefore hypothesized that symptoms of depression and suicidality would fluctuate over time in patients prone to suicidal behavior, depending on the degree of inflammation and kynurenine metabolite levels in the cerebrospinal fluid (CSF).},
  author       = {Bay-Richter, Cecilie and Linderholm, Klas R and Lim, Chai K and Samuelsson, Martin and Träskman Bendz, Lil and Guillemin, Gilles J and Erhardt, Sophie and Brundin, Lena},
  issn         = {1090-2139},
  language     = {eng},
  number       = {Aug 12},
  pages        = {110--117},
  publisher    = {Elsevier},
  series       = {Brain Behavior and Immunity},
  title        = {A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality.},
  url          = {http://dx.doi.org/10.1016/j.bbi.2014.07.012},
  volume       = {43},
  year         = {2015},
}